Thermo Fisher Scientific Staff Scientist, Bioinformatics in South San Francisco, California
Contribute to solutions driving easy, automated analysis of human genetic variation obtained by high-throughput sequencing;
Develop algorithms and applications deployed in production software for inferring biological knowledge from millions of short reads, and will optimize and validate application software;
Work on applications of next generation sequencing, including some or all of the following: detection of ultra-low frequency variants, detection of gene fusions, detection of deletions and other structural variants, quantitation of differential gene expression;
Contribute to inventing, speeding up, developing, evaluating, recommending, adapting, improving, optimizing, validating, integrating, documenting and supporting these analysis solutions;
Responsible for developing production-level software for these applications;
Will keep up to date with the latest developments in algorithms for analysis of next-generation sequencing and applications of sequencing, especially for personalized medicine and human health;
Give internal and external presentations, keeping abreast of the latest developments in genomics and genome medicine, and maintaining external contacts.
Ph.D. in Computational Biology, Bioinformatics, Computer Science or related field of study plus 5 years of bioinformatics and molecular biochemistry or related experience.
Must have experience or knowledge of:
Building model in complex arenas in Probabilistic Modeling, Markov Models, Hidden Markov Models, EM Algorithms, and Bayesian Networks;
Bioinformatics-R and Python programming;
Rapid prototyping and designing new applications;
Design new applications;
Bench experience in DNA or RNA sequencing technologies;
Experimentally assay design and hands-on experience in molecular biochemistry, cell biology and immunology;
Data analysis with Illumina, Ion Torrent and 454 platforms;
Analysis of data from metagenomics experiments;
SQL and scientific data management;
Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.