Merck Associate Principal Scientist, Neuroscience Early Discovery Genetics in Boston, Massachusetts
Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us. Our company is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. To this end, our company is intentionally at the forefront of applying genetics, genomics, and biological data science to advance breakthrough science and drug development across therapeutic areas.
Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.
The Genetics and Pharmacogenomics (GpGx) department at our research laboratory is currently seeking a Associate Principal Scientist with strong expertise in human genetics and the genomic basis for Neurological disease at the Boston site. Our mission in the Early Discovery Genetics group within GpGx is to identify and functionally validate novel targets anchored in human genetics that will enter our company's drug discovery pipeline for therapeutic intervention. The successful candidate will be team-oriented, with the ability to effectively communicate and thrive in an inclusionary, integrated, and multidisciplinary work environment. Specifically, the Senior Research Scientist will:
Integrate data from large human genetic datasets, including GWAS, RVAS, eQTL/pQTL studies, and Mendelian genetics, to identify potential therapeutic targets for Neuroscience disease areas.
Participate in large academic/industry partnerships and leverage data from large biobanks (including FINNGEN, UK Biobank)
Formulate and initiate functional validation studies of genetics targets in collaboration with experimental scientists in GpGx and with Neuroscience colleagues.
Collaborate closely with our neuroscience organization, statistical genetics colleagues and external partners to conceptualize, execute and apply genetics and genomics research for target identification and validation.
Work with cross-functional teams including disease area biologists, statistical geneticists. pharmacologists, chemists and external partners for the identification and validation of the genetics targets across the early discovery pipeline.
Communicate results, conclusions and application to program teams and therapeutic area leadership.
Provide genetics expertise to biologists and senior leadership across neuroscience disease areas.
Explore and identify new external collaborations with academia and industry partners to leverage tools to exploit human genetics/genomics in to discover new drug targets.
Spearhead both internal and peer-reviewed publications and presentations.
- PhD or MD/PhD with 4+ years of academic or industry experience after completing postdoctoral training in genetics, neuroscience diseases or related fields.
Proven track record and understanding of human genetics in neuroscience disease areas such as neurodegeneration, psychiatric, sensory and other neurological diseases to identify potential therapeutic targets.
Extensive experience in bioinformatics, statistics and data management to analyze large-scale genetic datasets as well as leverage genomics and epigenomics data to generate causal gene hypotheses.
Strong understanding of clinical/pathobiology functional readouts in neuroscience diseases for identifying translatable targets based on human genetics.
Experience in translating genetics findings into functional assays to provide insight into the biological mechanisms.
Strong communication, collaboration, and leadership skills including the ability to distill and communicate complex genetic/genomic concepts to scientists from diverse disciplines.
Demonstrate significant knowledge of neuronal networks and signaling, neuroanatomy and the interactions of diverse CNS cell types.
Experience with integration diverse high-throughput data types, as well as with big data architecture and visualization.
The geographic location of this position is in Boston MA.
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.
We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.
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Requisition ID: R63766
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