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Merck Functional Genomics Lead (Principal Scientist) - Boston, MA in Boston, Massachusetts

Job Description

We are seeking an experienced leader with expertise in functional genomics to join the Genome Sciences team within the Department of Genetics & Pharmacogenomics (GpGx) at our Research and Development (R&D) division in Boston. Our mission in Genome Sciences is to develop high-throughput cutting-edge genomic technologies to better understand disease mechanism and to accelerate the discovery of new targets and biomarkers across therapeutic areas. Our group utilizes innovative genetic screening and multi-omics single cell sequencing approaches to impact all stages of the pipeline from pre-clinical to clinical development. Genome Sciences collaborates closely with the discovery therapeutic areas (i.e., oncology, immunology, neuroscience, and cardiometabolic disease), pharmacology, and ChemBio groups within the Discovery, Preclinical and Early Development (DPED) organization to utilize these technologies to pursue key biological questions.

The responsibilities of the candidate include but are not limited to:

  • Leadership and management of a team of scientists with expertise in functional genomics

  • Overseeing the development of in vitro and in vivo assays that use a variety of technologies for measuring disease-relevant phenotypes and determining feasibility and best approach for incorporating an arrayed or pooled CRISPR-based genetic screen.

  • Identifying and developing new applications for CRISPR technology that can impact the drug development pipeline from target identification and validation, through biologics generation and manufacturing.

  • Collaborating closely with discovery therapeutic areas, pharmacology and ChemBio to enable the broad use of genetic screening to pursue key biological questions across broad areas of biology

  • Identifying strategic opportunities, both internal and external, to leverage innovative CRISPR technologies for therapeutic applications or to accelerate target and pathway biology discovery efforts at our Company

  • Written and verbal communication of study results to project teams and leadership, including proposals for further experiments to validate key findings

Education Minimum Requirement:

  • Ph.D. degree in cell and molecular biology, immunology, or related areas with 5+ years of post-graduate experience

Required Experience and Skills

  • Expertise in functional genomics approaches and integration across multi-disciplinary teams

  • Experience with high-throughput genomic technologies and analytical techniques for data interpretation

  • Experience directly managing and mentoring scientific researchers, and demonstrated ability to effectively lead a scientific group and work with efficiency and diplomacy as part of a team

  • Excellent leadership and organizational skills

  • Excellent verbal and written communication skills, including an ability to effectively communicate experimental design, results and conclusions

Preferred Experience and Skills

  • Prior biotech and/or pharmaceutical research experience

  • Experience screening high content chemical libraries

  • Experience working in a highly matrixed organization

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.





In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID: R15625