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Merck Senior Principal Scientist - Statistical Genetics Lead in Boston, Massachusetts

Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

Our Company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

We are currently recruiting for a key individual to contribute to Our Company’s human genetics effort. This Director will perform both a critical strategic role, as well as hands-on role, in overseeing the scientific direction of programs involving precision medicine for target identification and validation.

This Boston-based position will report into Executive Director of Early Discovery Genetics (EDG) within Genetics and Pharmacogenomics Department (GpGx). The qualified individual will be a recognized expert in field of statistical genetics, bioinformatics, or genetic epidemiology (with an emphasis on human genetics of complex traits) and have a strong understanding of functional interrogation of genetic findings, systems biology, and drug development. In addition to providing strategic and operational leadership, the incumbent will sit on the EDG management, lead a team of approximately 5 direct reports, and work closely with other teams in EDG and GpGx. He/she will be expected to operate in a highly collaborative environment, partnering with peers on site (all therapeutic areas, quantitative biosciences, chemistry, translational pharmacology) and at other research sites including New Jersey, Pennsylvania and South San Francisco. This position will also require extensive interactions with external partners, including leaders in academia as well as other Pharma/biotech companies.

Primary Responsibilities :

  • Participating as part of 5-person leadership team in developing, and driving, the strategy to identify and prioritize Targets entering the early pipeline across all therapeutic areas.

  • Leading a team of 5 individuals – including the hiring of new, outstanding scientists in statistical genetics, genetic epidemiology, and bioinformatics – responsible for applying these tools to target identification and validation rooted in human genetics.

  • Managing a budget responsible for the application of human genetics to drive target identification and validation.

  • Developing new external collaborations with academia and industry partners to leverage tools to exploit human genetics in order to discover new drug targets.

  • Partnering with a dedicated team of geneticists and functional biologists to build biological packages in support of targets that emerge from human genetics.

  • Engaging with internal peers in diverse areas – informatics, pharmacology, chemistry, therapeutic area biology, experimental medicine – to identify opportunities for drug development based on human genetic discoveries.

  • Integrate diverse ‘omics / biological datasets with human genetic data to identify novel pathways for drug development across all therapeutic areas.

  • Providing Genetics expertise.

  • Collaborating across functional areas and in a matrixed environment to develop integrated research plans, optimize resource allocation, and maximize efficiencies to best execute on programs.

  • Working with other data analysts and experimentalists to identify genes and variants associated with human phenotypes in families with rare Mendelian traits, as well as individuals from the general population, or distinct population cohorts;

  • Use of interrogation tools including Mendelian randomization and PheWAS (phenome-wide association study) to evaluate potential genetic targets for drug discovery

  • Written and verbal communication of study results to project team and the scientific community, including proposals for further experiments and publications in leading journals

Education Minimum Requirements:

  • MD or PhD required

Required Experience and Skills:

  • Demonstrated experience with a minimum of 6 years of experience in human statistical genetics, genetic epidemiology, or bioinformatics (peer reviewed publication, history of achievement, patents, etc.) with an appreciation of the role of human genetics for target identification and validation.

  • Demonstrated leadership skills.

  • Proven ability to create and work within high performance teams and/or matrix organization, strong influencing skills.

  • Demonstrated ability to conduct research individually and collaboratively and prioritize work against departmental and company goals.

  • Excellent oral and written communication skills, ability to establish and maintain productive cross-site and high caliber external collaborations.

  • Proficiency to critically evaluate scientific and therapeutic proposals and adopt novel technologies to facilitate groundbreaking research.

  • Proven track record in change management including ability to eliminate obstacles/barriers in order to implement change.

  • Ability to create partnerships with key stakeholders.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth .

INVENT.

IMPACT.

INSPIRE.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at [email protected]

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster at https://www.dol.gov/sites/dolgov/files/ofccp/regs/compliance/posters/pdf/eeopost.pdf

EEOC GINA Supplement​ at https://www.eeoc.gov/sites/default/files/migratedfiles/employers/eeocgina_supplement.pdf

OFCCP EEO Supplement at https://www.dol.gov/ofccp/regs/compliance/posters/pdf/OFCCPEEOSupplementFinalJRFQA508c.pdf

OFCCP Pay Transparency Rule at https://www.dol.gov/ofccp/pdf/pay-transp%20EnglishformattedESQA508c.pdf

We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:

1

Requisition ID: R52016

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