Merck Senior Scientist in Boston, Massachusetts
Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.
We are recruiting a highly motivated Senior Scientist with strong molecular immunology background and expertise in flow-based cell analysis and sorting to join the Protein Sciences Boston, Discovery Biologics to discover novel antibodies by in vitro display technologies. This is an exciting opportunity to collaborate with colleagues in Biology and Biologics teams at our company's Research Laboratories to champion projects and directly contribute to antibody discovery campaigns through lab-facing activities. The primary responsibility of Senior Scientist for this position is to identify, optimize, and engineer antibodies or binding proteins using in vitro display platform, such as Adimab yeast display technology. She/he will design antibody or binding protein selection and screening strategy for the desired specificity, affinity, functionality, and developability properties. In addition, the candidate will have an opportunity to explore novel protein-based or cellular modalities for the development of immune modulatory therapy. The successful candidate will have a strong track record of molecular engineering and a strong understanding human antibody repertoire, immune cell signaling and phenotypes, and the landscape of immune modulation. Experience in high-throughput selection and screening for biologics is a plus. She/he will be expected to apply essential molecular and cell biology skills to generate drug candidates that meet the design specifics.
Responsible for isolating and optimizing antibodies or binding proteins from yeast display libraries.
Exploring novel platform modalities for immune therapy
Take the lead within the laboratory and serve as subject matter expert
Execute experiments with automation methods using liquid handling equipment
Manage data within the project, collate and present the results in team meetings
Maintain a timely and accurate laboratory record of all activities
Work within a multidisciplinary and cross-functional team to advance biologics lead candidates
PhD within Biological Sciences (Immunology, Biology, Cell Biology, Biochemistry, Biotechnology, Bioengineering); or MSc with significant and relevant experience
Proficiency in flow cytometry including analysis, immune phenotyping and single cell sorting
Experience in the studies of humoral or cellular immunity
Proficiency in molecular biology skills
Familiar with computational antibody design tools for annotation and antibody repertoire analysis
Strong analytical and problem-solving skills
Excellent team working and communication skills
Track record of scientific publications and/or intellectual property generation
Expertise in yeast display for antibody selection and optimization
Experience with bioinformatics and NGS analysis
Experience with high throughput molecular cloning
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.
We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.
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No Travel Required
Flexible Work Arrangements:
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Number of Openings:
Requisition ID: R62172
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