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Principal Scientist, Innovative Lentiviral Cell and Gene Therapy

Agriculture and Forestry

Soil And Plant Scientist


Cambridge, Massachusetts, United States

6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients. The Biotherapeutic Engineering and Gene Therapy (BEGT) group is a part of the NIBR Biologics Center (NBC). BEGT drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics, AAV and lentiviral vectors. The NBC group works collaboratively with disease area groups to broaden the use of biologics in therapeutic applications. <br><br>As a Principal Scientist, you will bring an expertise in lentiviral gene therapies and lentivirus production and join a dynamic and experienced cell and gene therapy team at Novartis. You will be responsible for establishing and leading a new lentivirus production group for the generation and analysis of novel lentiviral vectors (LVV) and their cargo. This group will work closely with their disease area and analytics counterparts to merge the development of complex, next-generation lentiviral vectors with the growing need for innovative lentivirus production and characterization methods. This dynamic collaboration will be central to pushing the boundaries of possibility as we strive to improve efficacy and accessibility of gene therapies to patients.<br><br>What you’ll be doing:<br>Your responsibilities include, but are not limited to:<br>• Establish our internal LVV production platform for the production and purification of viral vectors that contribute to discovery research gene therapy projects in the research pipeline. <br>• Collaborate with viral vector design and analytical colleagues to implement process characterization tools and vector specific analytics for continuous improvement of production process and product quality. <br>• Coordinate with gene therapy and disease area groups outside of NBC to establish vector production needs. Work with NBC vector design and analytical leads to prioritize production schedule and efficiently execute workflow on time<br>• Present experimental designs, protocols, results and interpretations to a varied audience<br>• Maintain familiarity with current scientific literature and techniques in the field of virus production.<br>• Source and assess new equipment and technologies in order to expand and improve virus production and purification capabilities.<br>• Demonstrate good organizational and communication skills. Expected to be accountable for effectiveness and timelines of completion of project goals.<br>• Ability to balance multiple projects under a demanding timeline.<br><br>[#video#{#400,300#}#/video#]