Job was saved successfully.
Job was removed from Saved Jobs.

Job Details

Merck & Co, Inc

Associate Principal Scientist, Infectious Disease and Vaccines, Quantitative Pharmacology and Pharmacometrics

Agriculture and Forestry

Soil And Plant Scientist



Rahway, New Jersey, United States

Job Description

Our Quantitative Pharmacology and Pharmacometrics (QP2) Department is seeking a passionate, curious, and collaborative Associate Principal Scientist.

As an Associate Principal Scientist (Associate Director equivalent), you will participate on cross-functional teams of experienced scientists to discover and advance the clinical development of novel therapeutic agents for the treatment and prevention of infectious diseases. More specifically, you will apply your quantitative skills with minimal supervision to develop and implement translational PK/PD strategies, characterize clinical population pharmacokinetics and pharmacodynamics of biologics, small molecules, and vaccines, perform clinical trial simulations, comparator modeling and other model-based analyses to inform dose selection and schedule, clinical trial design and go/no-go decisions. You will apply your expertise to frame critical drug development questions to optimize drug development using model-based approaches and influence cross-functional teams to adopt such strategies. Finally, you will gain and maintain a comprehensive understanding of global regulatory expectations and contribute to regulatory documents and interactions with agencies.

The Associate Principal Scientist is a skilled modeler and a quantitative drug developer, with a strong, integrated understanding of the strategic elements of drug discovery and development and leads the QP2 strategic, executional, and operational efforts on a team. The ideal candidate is collaborative, possesses a learning mindset and can work through scientific challenges within and between departments to develop aligned strategies and solutions. Excellent communication skills are required including the ability to clearly present scientific data in group settings.

Within QP2, you have a unique opportunity to accelerate your professional career as a quantitative drug developer taking advantage of our end-to-end pipeline support in one of the world’s most research-intensive biopharmaceutical companies.


  • A Ph.D. or equivalent degree with at least 3 years of experience - OR- a PharmD or equivalent degree with at least 5 years of experience - OR- a MS or equivalent degree with at least 7 years of experience, where “experience” means having a record of increasing responsibility and independence in a similar role.

  • An educational background in PK/PD, pharmaceutical sciences, pharmacometrics, mathematics, statistics/ biostatistics, computational biology/chemistry, or chemical/biomedical engineering.

  • Experience in performing population PK / PKPD analyses using standard pharmacometric software (e.g. NONMEM, Monolix, Phoenix or other similar)

  • Experience in data analysis/interpretation and ability to visualize complex data using tool(s) (e.g. R, Python, Matlab)

  • Proficiency in written and verbal communication and interdisciplinary collaboration


  • An exemplary record of increasing responsibility, independence, and demonstrated impact in driving drug development decisions through application of model-based approaches

  • Knowledge of infectious diseases or vaccines.

  • Skills in experimental design, mathematical problem solving, and statistics

  • Scientific understanding of ADME and biopharmaceutic properties of biologics or small molecules

  • Demonstrated ability to participate in and to lead an interdisciplinary team

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

EEOC GINA Supplement​

OFCCP EEO Supplement

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here to request this role’s pay range.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:




VISA Sponsorship:


Travel Requirements:

Flexible Work Arrangements:

Remote Work


Valid Driving License:

Hazardous Material(s):

Number of Openings:


Requisition ID:R199355