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Merck & Co, Inc

Principal Scientist, Infectious Disease and Vaccines, Quantitative Pharmacology and Pharmacometrics

Agriculture and Forestry

Soil And Plant Scientist

Yearly

No

Rahway, New Jersey, United States

Job Description

Our Quantitative Pharmacology and Pharmacometrics (QP2) group is seeking a passionate, curious, and a collaborative Principal Scientist (equivalent to Scientific Director).

Principal Scientists in QP2 demonstrate advanced knowledge of how to apply quantitative approaches to drive model-informed drug and vaccine development. More specifically, they can independently impact key decisions on drug/vaccine development programs such as, inform dose selection, clinical trial design, and critical go/no-go decisions via translational PK/PD approaches, population PK/PD modeling, clinical trial simulation, model-based meta-analysis (MBMA), and quantitative systems pharmacology (QSP) models. In addition, Principal Scientists shape, present and defend regulatory strategies to support global regulatory submissions and post-approval expansions in indications. They are excellent communicators and demonstrate outstanding leadership skills. Principal Scientists perform job duties independently with minimal supervision, lead QP2 efforts on drug/vaccine development programs, author strategic documents, and contribute to business development assessments.

Within QP2, you have a unique opportunity to accelerate your professional career as a quantitative drug developer taking advantage of our end-to-end pipeline support in one of the world’s most research-intensive biopharmaceutical companies. This role will be focused on efforts in the infectious disease therapeutic area within the Infectious Disease/Vaccine group of QP2

Required:

  • A Ph.D. or equivalent degree with at least seven years of experience – OR - a PharmD or equivalent degree with at least nine years of experience -OR- an MS or equivalent degree with at least 11 years of experience, where “experience” means having a record of increasing responsibility, independence and demonstrated impact in driving drug/vaccine development decisions through application of model-based approaches.

  • An educational background in Quantitative Clinical Pharmacology, Pharmacometrics, Pharmaceutical Sciences, Mathematics, Statistics/Biostatistics, computational biology/chemistry, chemical/biomedical engineering, or a related field.

  • Experience with performing population PK/PD analyses using standard pharmacometrics software(s) (e.g. NONMEM, Phoenix, Monolix or other similar)

  • Expertise in critical data analysis/interpretation and ability to visualize complex data using tool(s) (e.g. R, Python, Matlab)

Preferred:

  • Experience in developing and conducting model-based meta-analysis (MBMA).

  • Knowledge of infectious diseases or vaccines.

  • Direct experience in regulatory interactions and filing with the ability to influence regulatory strategies including independently formulating registration packages to support global filings, a strong understanding of clinical pharmacology studies to support intrinsic/extrinsic factors, ability to independently author, defend regulatory filings.

  • Proficiency in written and verbal communication, interdisciplinary collaboration, and problem scoping and planning.

  • Demonstrated ability to effectively communicate in, and lead an interdisciplinary team, and to have mentored junior scientists/peers.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

EEOC GINA Supplement​

OFCCP EEO Supplement

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here to request this role’s pay range.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

Flexible Work Arrangements:

Remote Work

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:

1

Requisition ID:R199360