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Merck & Co, Inc

Senior Scientist, Spatial Transcriptomics and Multi-omics Sequencing

Agriculture and Forestry

Soil And Plant Scientist


Cambridge, Massachusetts, United States

Job Description

We are seeking a passionate experimental biologist or hybrid scientist with expertise in spatial transcriptomics and/or single cell sequencing experimental research to join the Genome Sciences team within the Department of Data & Genome Sciences (DGS) at Our Company's Research Laboratories in Cambridge, MA. Our group utilizes innovative Spatial Transcriptomics (Visium, MERSCOPE, CosMx, Xenium) and multi-omics single cell approaches (REAP-seq/CITE-seq, CROP-seq/Perturb-Seq, Immune profiling, Multiome ATAC-seq) to impact all stages of the drug development pipeline from pre-clinical to clinical development. Genome Sciences collaborates closely with the discovery therapeutic areas (i.e., oncology, immunology, neuroscience and cardiometabolic disease) and functional areas (i.e. Data & Genome Sciences, Data Science & Scientific Informatics, Quantitative Bioscience, and ChemBio) within the Discovery, Preclinical and Translational Medicine (DPTM) organization to leverage these leading edge technologies for novel target and biomarker identification and validation or to better understand therapeutic mechanisms of action for diseases with high unmet need.

We are seeking a passionate experimental biologist or hybrid scientist that will be involved in both data generation and data analysis with expertise in high-throughput genomic technologies to join our group. In this position, you will be based at our Research Lab in Cambridge, MA and contribute to the development and execution of spatial transcriptomics experiments. Successful candidates will be an active participant in the scientific dialogue of the group and will be able to work independently and proactively collaborate with colleagues.

The responsibilities of the candidate include but are not limited to:

  • Pioneering experimental capabilities for high resolution spatial transcriptomics to enable deep interrogation of gene expression across tissue sections

  • Designing, preparing and executing experiments utilizing multiple spatial transcriptomics platforms (i.e., MERFISH, Visium, Xenium, CosMx) with intact human and preclinical tissues.

  • Analyzing tissue sections from patient samples and pre-clinical models to better characterize cellular cross-talk, distribution in disease, and study biological mechanism in relation to efficacy.

  • Handling fresh frozen and FFPE tissue specimens, including sectioning, staining, imaging, and analysis

  • Troubleshooting and optimizing tissue processing, imaging and/or Next Generation Sequencing (NGS) workflows to ensure high level of quality and reliability of generated results

  • Performing analysis of digital pathology and spatial transcriptomics data using advanced software platforms and/or command line tools (e.g. R, Python)

Education Minimum Requirement: Ph.D. in in molecular and cell biology or related disciplines

Required skills and experiences:

  • Hands-on expertise in molecular biology assays, especially high throughput genomic technologies including single cell RNA-seq or spatial transcriptomics

  • Familiarity with immunohistochemistry, in situ hybridization or other related histological techniques

  • Demonstrated expertise in Oncology and/or Immunology therapeutic area research

  • Keen understanding of experimental design, underlying scientific principles, and the ability to rigorously analyze and document results

  • Being proactive and collaborating closely across multi-disciplinary groups including, Oncology, Neuroscience, Immunology, CMD, Data & Genome Sciences, Data Science & Scientific Informatics

  • Strong communication (oral and written) and collaboration, including an ability to effectively communicate experimental design, results and conclusions

Preferred Experience and Skills

  • Demonstrated experience in computational analysis and interpretation of spatial transcriptomics, spatial proteomics, single cell RNA-seq and/or Total-Seq datasets

  • Experience using Linux/Unix OS and high-performance compute (HPC) environments. Familiarity with coding in R and/or Python

  • Publications in high impact journal.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

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For positions located in the United States and Puerto Rico – Subject to applicable law, all new hires (including internal transfers) must demonstrate that they are fully vaccinated against COVID-19 or that they qualify for a medical or religious exemption to this vaccination requirement. New hires (including internal transfers) to a position that, as determined by the Company, requires routine collaboration with external stakeholders (such as roles in health services or customer-facing commercial or research-based roles) (“Customer-Facing Role”) who are not vaccinated must qualify for a medical or religious exemption and be in a position that the Company determines can accommodate unvaccinated employees without causing an undue burden to business operations. If, following dialog with the candidate as appropriate, it is determined that the candidate either a) does not qualify for a religious or medical exemption or, b) for candidates applying for Customer-Facing roles, it is determined that allowing the candidate to work without vaccination would cause an undue burden to the Company, the candidate will be ineligible for hire or transfer, or any offer of employment or transfer (if applicable) will be revoked. Please note that notwithstanding the approval of any reasonable accommodation, the Company reserves the right to monitor, modify, or revoke any such accommodation if it is determined, following dialog with the employee, that the accommodation is no longer effective or results in an undue burden to the Company.

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Residents of Colorado:

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Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R215008