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Principal Scientist, Cardiovascular and Metabolic Disease Area (CVM)

Agriculture and Forestry

Soil And Plant Scientist


Cambridge, Massachusetts, United States

Cardiovascular disease remains the leading cause of death for both men and women. The Cardiovascular and Metabolic (CVM) Disease Area at NIBR in Cambridge, Massachusetts is committed to discovering transformative medicines to treat cardiovascular and metabolic disorders. We are seeking a highly motivated scientist who can join our Metabolic disease team to work at the bench and lead exploratory efforts (target discovery and validation) as well as drug development projects that contribute to the science and treatment of Cardiovascular and Metabolic disease. <br><br>What you will be doing: <br><br>•Initially, the successful candidate will spend most of the time thinking about skeletal muscle energy expenditure, generating hypotheses and testing them in the lab (bench work is initially part of the expectation). The project(s) will be in the field of Metabolic Diseases (obesity) and range from target concept to IND-enabling studies.<br>•Most of the candidate’s efforts will be in applying cell biological and biochemical methods. Enthusiasm for studying the effects of low molecular weight drugs, peptides, antibodies, and especially siRNA is important.<br>•With time and experience, the candidate will lead project teams and productively collaborate across the Novartis research organization in the many disciplines re-quired for drug development (medicinal chemistry, biologics development, safe-ty, etc.) as well as recognize and leverage external collaboration opportunities that amplify the Department’s research.<br>•In time the candidate is expected to develop expertise in the any of the fields of Heart Failure, Atherosclerosis, Arrhythmia, or Metabolic Disease. Prior experience in one of these areas is a plus but is not required.<br>•Learn from other members in the Department, and mentor other less experienced bench scientists. The ability and interest to interact with and assist others is vital.<br>•Excellent verbal and written communication skills are necessary.<br><br>The pay range for this position at commencement of employment is expected to be between $102,400.00 and $169,200.00 per year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.<br><br>[#video#{#400,300#}#/video#]