Senior Scientist: High-Content Screening and Cell-Painting

Job Description

Attention NJ Applicants: In April 2020, our Company announced plans to consolidate our New Jersey campuses into a single New Jersey headquarters location in Rahway, NJ by 2023. Therefore, the NJ work location for this role will be temporarily based and the exact timing of the departmental move to Rahway, NJ will be communicated at a future date.

The Screening & Compound Profiling Group is seeking a highly motivated Senior Scientist with a strong background in the development of physiological relevant cellular assays to join our Quantitative Biosciences Department at our Research Laboratories in Kenilworth, NJ. The primary responsibilities of the successful candidate will be to develop cell pharmacology assays to support screening small molecules, peptides and arrayed CRISPR for oncology, immunology, neuroscience and cardiovascular disease areas. The ideal candidate will have experience with a variety of cell-based assays, with an emphasis on complex cellular models and high-content image analysis and functional genomics. Knowledge and understanding of miniaturized assays (384w/ 1536w) and downstream detectors ranging from standard luminescence-/fluorescence-based readouts to imaging and cell-microarray based platforms is desired. Using innovative thinking, state-of-the-art facilities, and robust scientific methodology we collaborate to discover the next medical breakthrough.

Key Functions

• Work independently and as a Team member with Integrity | Precision | Accomplishment | Motivational Ambition | Respect | Inclusion.

• Direct experience in cellular assay development with proficiency in high-content screening and image analysis using primary cultures and cell lines.

• Focus on high throughput (HT)-complex cell models (3D, iPSC, co-culture systems) to enable the development of ‘assays at scale.’

• Ability and willingness to think “outside the box” to develop and adopt emerging cell biology technologies to support HTS (i.e. microfluidics, cell microarray platforms)

• Collaborate with Project teams to develop innovative approaches to target-based and phenotypic screening for small molecule discovery efforts.

• Oversee and manage the design, planning and execution of robust scientific research activities.

• Solid understanding of data analysis workflows and statistical principles as well as AI/ML used in screening.

• Collaborate in an integrated, multidisciplinary team environment.

Minimum education required:

• Bachelor or Master or PhD degree

Required experience and skills:

• Bachelor Degree: Ten years experience | Master Degree: Three to six years experience | PhD Degree: Zero to three years (All three degree level experience must be in assay development and high throughput screening, with the ability to succeed in a collaborative, highly matrixed environment)

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

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Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Under New York City, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected salary range:

Available benefits include bonus eligibility, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. For Washington State Jobs, a summary of benefits is listed here.

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Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Relocation:

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Flexible Work Arrangements:

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Requisition ID:R222674