Scientist, Gene Delivery Process Development

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Scientist, Gene Delivery Process Development

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Cell Therapy is one of the most groundbreaking new forms of cancer treatment being studied today. With therapies only in their infancy and BMS’s continued investment in our Cell Therapy capabilities, the growth potential of this science, your career, and the ability to help patients are incredible.

We are seeking an enthusiastic, self-driven individual to join the Gene Delivery Process & Analytical Development team. Our team develops process and technology underpinning critical raw materials used in the manufacturing of engineered T cells, including guide RNA and CRISPR enzymes. This Scientist role will be responsible for providing technical subject matter expertise with internal and external development and manufacturing collaborators including supporting deviation closure, ensuring the processes meet qTPP and specifications, and contributing to comparability assessments due to any process changes. The candidate will also contribute to wet lab experimental design and execution for gene editing raw materials to support current programs and advance our understanding in gene editing raw materials.

Responsibilities:

• Plan and execute experiments to support the implementation of process improvements to RNP complexation unit operations and RNP performance
• Serve as the technical subject matter expert (SME) for gene editing process development
• Establish standard workflow and documentation for RNP process definition
• Work with internal collaborators to determine nucleic acid and RNP Quality Target Product Profiles (qTPP)
• Evaluate new high throughput techniques to assess gene editing reagent quality
• Manage projects with contract manufacturers to produce GMP-grade nucleic acids and enzymes
• Author technical reports, patents, peer-reviewed publications, and regulatory documents

Basic Qualifications:

• Degree in Bioengineering, Biochemistry, Protein Engineering, or related discipline
• 6+ years (B.S. or M.S.) or 0 – 2 years (Ph.D.) of experience
• Familiarity with mammalian cell culture, preferably with primary cells.
• Extensive knowledge and experience with CRISPR-Cas systems
• Documented experience manufacturing gene editing raw materials for clinical or research applications
• Effective communication including presentations to convey scientific concepts to research scientists, management teams, and external academic and industrial organizations
• Proven ability to work effectively as a member of a multidisciplinary team
• Strong organization, problem-solving, and project management skills with attention to detail
• Experience and working knowledge of concepts including but not limited to genetic engineering; nucleic acid and enzyme production, purification, and analytical methods; and gene therapy

Preferred Qualifications:

• Previous work interfacing with contract manufacturing and development organizations
• Experience developing GMP manufacturing processes for globally regulated products, such as vaccines, biologics, or cell & gene therapies
• Experience in analytical techniques and analysis related to nucleic acids and CRISPR-enzymes including SDS-PAGE, HPLC, ddPCR, Next-Generation Sequence (NGS), dynamic light scattering (DLS) and ICE-Seq
• Previous work biochemically characterizing enzymes including enzyme kinetics, structural elucidation or mechanism of action

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.