Associate Principal Scientist, LC-MS Method Development
The Department of PCD Regulated Bioanalytics, PK & ADA Bioanalysis is seeking an experienced bioanalytical scientist to join our Regulated LC-MS Method Development group located in West Point, PA. Demonstrated expertise in the field of the bioanalysis of small molecules and biotherapeutics via liquid chromatography/mass spectrometric (LC-MS) methods in support of regulated drug development studies is required. In this position, the candidate will be responsible for developing bioanalytical methods for the quantitation of drug candidates in biological matrices to support Good Laboratory Practice (GLP) and clinical studies.
Develop regulated bioanalytical methods for the quantitation of small molecule and biotherapeutic drug candidates using LC-MS based platforms including triple quadrupole (QQQ) and high resolution (HRMS) mass spectrometers.
Independently manage bioanalytical deliverables for assigned program(s) and drive the science on a day-to-day basis with broad project goals.
Be a champion of innovation with a keen eye on the latest developments in the field of mass spectrometry of biotherapeutics.,
Education Minimum Requirements:
Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences or related discipline with a minimum 4 years relevant experience.
Master’s Degree with a minimum 8 years of relevant experience.
Bachelor’s with a minimum of 12 years of relevant experience.
Required Experience and Skills:
Advanced experience in bioanalytical quantitation by LC-MS including analysis of peptides and large molecules.
Extensive experience in biochemical techniques for sample preparation.
Extensive experience in LC-MS instrumentation and trouble shooting.
Track record in developing chromatographic assays for pre-clinical and/or clinical applications.
In-depth understanding of the drug development process.
Ability to lead the development of new, innovative bioanalytical approaches and experimental designs.
Strong leadership, interpersonal, communication, collaboration and problem-solving skills.
Excellent verbal and written communication skills.
Proven record of scientific publications and presentations at scientific meetings.
Preferred Experience and Skills:
Experience in Ligand Binding Assay-based bioanalytical method development and validation in addition to mass spectrometric methods will be consider a plus.
Experience with liquid handlers and other automation platforms for sample preparation and assay process.
Proficiency in various bioinformatics tools such as Skyline, Proteome Discoverer, MaxQuant, and database search engines.
Knowledge of the basic principles of regulated bioanalysis and Good Laboratory Practice (GLP).
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
Residents of Colorado
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New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.
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Residents of Colorado:
Click here to request this role’s pay range.
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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
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