Senior Scientist, Lentivirus Upstream Early Pipeline Development

6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients. The Biologics Center (NBC) is accommodated within the Novartis Institutes for BioMedical Research (NIBR). NBC, in collaboration with the disease areas and technical expert groups, builds the future biologics therapy pipeline of Novartis through the discovery and creation of new antibody, protein, nucleic acid and virus-based molecules.<br><br>The Senior Scientist, Upstream Early Pipeline Development, will be responsible for executing early-stage process development with the focus on developability for early-stage lentivirus (LVV) gene therapy pipeline portfolio as well as new platform process for existing and novel LVV pseudotypes and cargo vectors. <br><br>What you’ll be doing: Your responsibilities include, but are not limited to:<br>• Develop and execute suspension small-scale shake flask and bioreactor-based cell culture processes for manufacturing of LVV gene therapy vectors across multiple preclinical programs and disease areas to ensure on time delivery.<br>• Lead collaboratively in operational and strategic discussion within a global team.<br>• Design and execute experiments to drive innovative technology and platform evaluation for next generation cargo vectors and LVV envelope pseudotypes and work collaboratively with downstream process development and analytical development teams. <br>• Serve as interface with downstream, Disease Areas and platform/technology teams to drive early drug discovery from target selection and validation through lead compound selection and developability assessment<br>• Work collaboratively with Cell Line Development, Characterization and Formulation colleagues to develop and optimized workflow for next generation LVV manufacture and analytics. <br>• Serve as an interface to transfer knowledge and work collaboratively with Technical Research & Development team to advance pipeline programs into clinical phases.<br>• Provide technical support, training, and SME knowledge to assist with the development of junior associates.<br>• Prepare protocols, reports and provide high quality data and electronic notebook documentation. <br>• Other related job duties as assigned.<br><br>This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will require 0% travel as defined by the business (domestic and/ or international).<br><br>[#video#https://www.youtube.com/watch?v=ggbnzRY9z8w{#400,300#}#/video#]