Senior Scientist - Cell Engineering & Process Design

Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology, we collaborate to discover the next medical breakthrough.

Our Company's Bioprocess is seeking a highly motivated and experienced Senior Scientist to advance the cell engineering & process design capability for primary hematopoietic cells. The Senior Scientist will support biotherapeutics development pipeline and technology innovation in areas such as primary blood cell isolation, T/NK cell activation and differentiation, and ex vivo gene editing. The successful candidate should have an in-depth understanding of immunology, T/NK cell development, stem cell biology, molecular biology, and cell signaling. Candidate should have hand-on experience in these areas, including primary hematopoietic cell culture, iPSC and/or ES cell culture, vector engineering, multi-color flow cytometry panel design and Western blotting analysis for RTK signaling. The selected candidate will be expected to work independently and stay up to date on the knowledge of principles and theories related to new and emerging technologies. The selected candidate will be developed as a functional area representative and leader on project teams. Responsibilities include, but are not limited to:

Primary Responsibilities:

• Multi-color flow panel design and operation.

• Cell culture of primary hematopoietic cells including isolation, activation and cryopreservation.

• T and NK cell subset characterization using flow cytometry.

• Vector construction and engineering to modulate expression.

• Lentiviral vector construction and generation.

• RTK signaling analysis by Western blotting and other related approach.

Education Minimum Requirements:

• PhD in Immunology or

• MS in related Biological Sciences with at least four years of the experience in multicolor flow cytometry and primary T lymphocyte culture.

Required Experience and Skills:

• Expertise in multi-color flow panel design and immunophenotyping of human PBMCs lineage and T cell differentiation subsets.

• Expertise of tools of flow cytometry data analysis, such as FlowJo.

• Experienced in primary lymphocyte isolation and culture.

• Expertise in immunological assays related to T cell signaling and cellular functions.

Preferred Experience and Skills:

• Primary NK cell culture and expansion.

• Vector construction and engineering to modulate expression.

• Lentiviral vector construction and generation.

• Expertise of Western blotting and RTK signaling study.

• Familiar with omics databases and bioinformatics tools.

• Experience with cell engineering (e.g., CRISPR)

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.

IMPACT.

INSPIRE.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:

Requisition ID:R101790