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Job Details

Medical Director-Nephrology/Genetic diseases (Translational Medicine)


Executive Director


Cambridge, Massachusetts, United States

Medical Director-Nephrology/Genetic diseases (Translational Medicine)

Job ID


Jan 25, 2024


About the Role

This position will be on-site and will not have the ability to be located remotely. The position can be in Cambridge, Massachusetts (USA) or Basel (Switzerland); Basel is preferred for co-location with most of the disease area scientists.

Over 2 million! That’s the number of people worldwide currently relying on dialysis or kidney transplants to survive. However, this number represent less than 10% of the actual number requiring treatment for their kidney diseases.

As a Translational Medicine Expert (TME), you will provide medical and scientific expertise that drives the success of early drug development, global clinical studies, and strategies to achieve clinical Proof-of-Concept in the Nephrology disease area, and to progress towards new treatments for unmet medical needs.

About Translational Medicine at Novartis

Translational Medicine is a global group of scientists and physicians working at the pre-clinical and early clinical stage of drug discovery.

Our physician-scientist discovery & profiling (TMDP) group drives innovative and cutting–edge science from discovery to the market through the selection, profiling and effective global development of successful medicines. The group closes the gap between preclinical research and clinical development and integrates clinical science into the discovery and preclinical development phase. Our Translational Medicine concepts are driven by medical needs of the patient and the concept of personalized medicine, tailoring the drug, its dose and dosing regimen in such way to the patient that the clinical response is optimal in terms of efficacy and safety.

We focus from identification of drug targets (molecular pathways relevant to disease) up to the completion of Proof-of-Concept (Phase 2a studies). Our Translational Medicine Experts (TME) are part of preclinical project teams in all drug discovery phases and help design the pathway for First in Human (FIH) studies (healthy volunteer) that bridge to studies in the patient population. They have the comprehensive responsibility for designing and executing the early clinical drug development phase together with a project team from researcher, biomarkers, biostatistics, modelling & simulation, toxicology, technical experts and the clinical trial teams.

After the completion of a successful Phase 2a study the drug progresses to full development for Phase 2b and Phase 3 study design and further drug development.

Your role in Translational Medicine

  • In collaboration with your Translational Medicine Head and other line function experts, develop high value decision-strategies for the Translational Medicine component of drug development projects through the Proof-of-Concept phase
  • Lead global project teams through Phase 2 to drive implementation of the project strategy; participate in cross-functional project meetings through the program life cycle from target review to registration
  • Responsible for clinical portions of the Integrated Development Plan through Phase 2
  • Responsible for implementation of early clinical studies by providing medical and scientific leadership and expertise to all line functions on the project team; this may include methodology studies to identify and validate novel endpoints for early decision making
  • Participate in analysis of studies and present results to relevant decision boards
  • Medical monitor for one or more global clinical studies
  • Communicate clinical team matters to project teams and relevant decision boards
  • Convene relevant (internal and external) leaders together to consider the proposed development strategy
  • Evaluate clinical centers and foster communication with collaborating investigators
  • Oversee publication and external presentation of clinical study results
  • Accountable for compound related biomarker strategies in close collaboration with biomarker experts
  • In collaboration with research scientists, identify, develop and implement strategy for pre-clinical support of program-related objectives; this may include assessment of medical need, proposal of clinical development pathways, and review of pre-clinical data for clinical implications, and other relevant activities
  • Participate in team presentations to health authorities as clinical development expert
  • Prepare and implement disease area or project-specific trainings and educational programs for colleagues from Translational Medicine and other line functions; mentor Translational Medicine colleagues on scientific, clinical, and drug development issues
  • Contribute to initiatives that drive innovation, quality, and efficiency across Translational Medicine

Diversity & Inclusion / EEO

We are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please let us know the nature of your request, your contact information and the job requisition number in your message:

Role Requirements

Experience and Skills Required:

  • Medical Degree, Board certified Nephrologist
  • PhD-level basic science supported with high quality publications; a completed postdoctoral fellowship is strongly preferred
  • Adult Nephrology expertise is preferred to bring additional skills to the team
  • Expertise in genetically inherited kidney / inflammasome / inflammatory diseases; alternatively, cell therapies / rheumatologic diseases
  • Experienced clinician treating relevant patient groups at an academic medical center or private medical practice group
  • Experience performing in a similar role within an Pharmaceutical research company is preferred, otherwise a Clinical Research Organization or academic medical center
  • Significant evidence of successful collaboration with expert disease research scientists
  • Used to leading complex cross-functional/matrix project teams
  • Advanced/business-level/fluent English

Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here:

You’ll receive:

You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook.

Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams’ representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1[Register to View] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $257,600 - $386,400/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here:


Biomedical Research

Business Unit

Translational Medicine




Cambridge, MA

Company / Legal Entity


Functional Area

Research & Development

Job Type

Full Time

Employment Type


Shift Work