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Job Details

Bristol Myers Squibb

Senior Manager, Downstream Manufacturing

Manufacturing and Production

Manufacturing Engineering Manager


Devens, Massachusetts, United States

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

The Downstream Senior Manager leads and drives the execution of commercial manufacturing processes according to established electronic work instructions and production records for the manufacture of therapeutic proteins in accordance with Current Good Manufacturing Practices (cGMP’s). The Senior Manager is responsible for management of group whose primary focus is on execution of manufacturing processes, technical assessment of processes, maintaining a culture of compliance, innovation, and within their functional group. The Senior Manager is required to guide the personnel in their group with knowledge and technical knowledge to lead troubleshooting activities, provide investigation support, analyze process/equipment data, and identify and implement process improvements.


  • Drives site schedule by prioritizing resources/activities for manufacturing and support functions Leads one or more operational groups, ensuing department goals and metrics are meeting or exceeding expectations.

  • Identifies deficiencies, creates and executes action plans to mitigate issues. Is responsible for the performance of all reporting team members.

  • Takes an active role in developing less experienced team members. This includes leveraging both internal and external relationships to build the best team possible.

  • Coordinates response to any developing issues and escalates as appropriate.

  • Ensures team adherence to Good Manufacturing Practices and safe work practices.

  • Ensures daily work coordination and distribution of work as demanded through the manufacturing schedule. Manage to schedule and plan.

  • Recognize impact for cross functional impact. Any variance to be captured and communicated to cross functional groups in real time Build partnership with Manufacturing Support to ensure seamless operations.

  • Provide communications upwards, downward and across as deemed fit

  • Manage decisions– acquire feedback, input, and consult as required Manages performance.

  • Provide coaching, mentoring and development of staff. Conducts powerful conversations and provides meaningful and actionable feedback for staff growth and development.

  • Executes all phases of the performance review process with diligence and on time.

  • Develops operational schedule in conjunction with scheduling and planning team.

  • Drives increased scheduled adherence and cycle time. Drives continuous improvements through staff engagement

  • Demonstrated ability to lead manufacturing operations teams to achieve objectives. Acts to promote a productive and cooperative climate.

  • Helps to promote team effectiveness by engaging in a trusting, supportive partnership with others.

  • Encourages or facilitates a beneficial resolution of purpose. Resolve conflicts in a constructive manner that allows win/win solution

  • Demonstrated ability to prioritize and coordinate activities within and across work groups; able to anticipate priority differences and issues and resolves these before problems occur, exceeds desired results.

  • Participates in the budget development process; effectively controls expenses (OT, Supplies, T&E) within their influence.

  • Develops stretch goals and uses effective motivation techniques to achieve them. Strong team diagnostic skill and strategy for team growth.

  • Shapes site goals and policies.

  • Able to effectively lead cross functional teams.

  • Provides shift continuity by attending the daily scheduling and triage meetings.

  • Attends active maintenance, frozen schedule, and IEF meetings as a standing member.

  • Provides direct audit support.

  • Leads CAPA and eCC child actions to meet target due dates.

  • Drives accountability through Tier Meetings Department approver of MBRs, BOMs, SOPs and other manufacturing documentation.

  • Works with Site Leadership to develop and implement strategic initiatives. Acts as a consultant to project teams.

  • Provides on call support for the manufacturing team including active participation on the weekend and holidays.


  • Knowledge of science generally attained through studies resulting in a B.S., in science, engineering, biochemistry or related discipline, or its equivalent is highly desired.

  • Direct biologic manufacturing experience of 8+ years with minimum of 3+ years of previous supervisory experience which demonstrates proficiency in selection of team and effectively managing personnel issues is required.

  • Mastery of SOPs and cGMPs within a regulatory environment.

  • Experience with cell culture operations is highly desirable.

  • Extensive knowledge of biopharmaceutical manufacturing process with a proven record in pharmaceutical technology, technology transfer, process development, manufacturing support.

  • Demonstrated aptitude for engineering principles and manufacturing automation systems.

  • Previous cross-functional supervisory experience which demonstrates proficiency in selection, motivating and retaining a superior team, effectively managing personnel issues and planning and administering financial resources.

  • Adaptable to a fast paced, complex and ever-changing business environment.

  • Effective communication and technical writing skills with support groups in the coordinating system to obtain needed cooperation and support as required in a timely and effectively manner.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.