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Merck & Co, Inc

Associate Principal Statistical Programmer, Real World Evidence (Remote) ( MERCUSR187245ENUS)

Real Estate




Upper Gwynedd, Pennsylvania, United States

Job Description

This position provides high quality statistical programming analysis and reporting deliverables on Real World Evidence projects for a variety of customers across the company's Biostatistics and Research Decision Sciences (BARDS) and the company Center for Observational Research and Real World Evidence (CORE) groups. The associate principal statistical programmer utilizes strong expertise in multiple programming languages including SAS and R to efficiently manipulate electronic healthcare databases to discover disease prevalence and risk factors, describe drug utilization patterns and disease progression, support market research, and answer clinical development questions. In this role, the associate principal statistical programmer will gather and interpret user requirements from CORE outcomes research scientists and BARDS epidemiologists, retrieve the required data from electronic healthcare databases, and develop disease cohorts, analytical datasets, tables and figures and perform validation activities following departmental SOPs. The associate principal statistical programmer will be a key collaborator with CORE scientists and BARDS epidemiologists to execute project plans efficiently and oversee the work of other team members when opportunities arise.

Education Minimum Requirement:

  • MS in Computer Science, Statistics, Applied Mathematics, Life Sciences, Engineering or related analytical field plus minimum 7 yrs experience in multiple programming languages including SAS and R

  • BA/BS in Computer Science, Statistics, Applied Mathematics, Life Sciences, Engineering or related analytical field plus 9-12 yrs experience in multiple programming languages including SAS and R

Required Experience and Skills:

  • Excellent interpersonal skills and ability to negotiate and collaborate effectively

  • Excellent written, oral, and presentation skills

  • Broad knowledge and significant experience in developing analysis and reporting deliverables for R&D projects (data, analyses, tables, graphics, listings)

  • Strong project management skills; leadership at a program level; determines approach and ensures consistency and directs development of others when opportunities arise; ability to engage key stakeholders

  • Significant expertise in SAS and R Real World Evidence programming including data processing, statistical procedures and graphing and tabulation techniques; systems and database expertise

  • Designs and develops programming algorithms

  • Ability to quickly and effectively learn new program techniques and data structures; capacity to seamlessly assimilate to new projects

  • Ability to comprehend data analysis plans which may describe observational research and statistical methodology to be programmed; understanding and implementation of observational research or statistical terminology and concepts; implements observational methods not currently available through commercial software packages

  • Programming expertise with electronic healthcare databases (electronic medical records and insurance claims); efficiently manipulates large databases including complex data preprocessing, filtering, and manipulation; experience with sampling strategies for large databases

  • Unix operating system experience; SQL experience; systems and database experience

  • Thrives working in an exploratory environment, handling non-standard data in a variety of formats with minimal requirements

  • Demonstrated success in the assurance of deliverable quality and process compliance. Strong working knowledge of reporting processes (SOPs) and software development life-cycle (SDLC);

  • An interest to advance career by investing in development activities and taking on tasks with increasing levels of challenge and responsibility

  • Team oriented with demonstrated history of teamwork and collaboration; enjoying diversity, respect and integrity

Preferred Experience and Skills:

  • Strategic thinking - ability to turn strategy into tactical activities; design of statistical databases with the end in mind that optimize analysis and reporting and leverage departmental standards and industry best-practices

  • Experience in process improvement; utilizes and contributes to the development of standard departmental SAS macros and R code and tools

  • Familiarity with the fields of Outcomes Research and Epidemiology

  • Experience with Common Data Model (CDM)

  • Experience in version control tools (e.g. git, github, bitbucket)

  • Experience working with coding systems such ICD-9, READ/OXMIS, and ICD-10

  • Good working knowledge of reporting processes (SOPs) and software development life-cycle (SDLC)

  • Experience eliciting user requirements and documenting programming specifications

  • Understanding of statistics, clinical and data management concepts as applied to drug/vaccine development within the pharmaceutical industry;

  • Experience assuring programming consistency across protocols and projects, directing the program development effort of other programmers; experience as a programming mentor

  • Ability to anticipate stakeholder requirements

  • Ability and interest to work across cultures and geographies

  • Active in professional societies

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.


Who we are …

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

Click here to request this role’s pay range.

New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.

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Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R187245