Associate Principal Scientist, Quantitative Pharmacology and Pharmacometrics

Job Description

New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in customer facing commercial or research based roles, will be required to be fully vaccinated as a condition of employment.

Our Quantitative Sciences team use big data to analyze the safety and efficacy claims of our potential medical breakthroughs. We review the quality and reliability of clinical studies using deep scientific knowledge, statistical analysis and high-quality data to support decision making in clinical trials.

The Quantitative Pharmacology and Pharmacometrics (QP2) Department of our company's Research Laboratories in West Point, PA / Rahway, NJ is seeking a curious and collaborative Associate Principal Scientist.

As an Associate Principal Scientist, you will participate on cross-functional teams of experienced scientists to discover and advance the clinical development of novel therapeutic agents for cardiometabolic, ophthalmic or immunologic disorders. More specifically, you will apply your quantitative skills with minimal supervision to develop and implement translational PK/PD strategies, characterize clinical population pharmacokinetics and pharmacodynamics of biologics, small molecules and non-traditional therapeutics like peptides, novel biological constructs and others, perform clinical trial simulations, comparator modeling and other model-based analyses to inform dose selection and schedule, clinical trial design and go/no-go decisions. You will apply your expertise to frame critical drug development questions to optimize drug development using model-based approaches and influence cross-functional teams to adopt such strategies. Finally, you maintain a comprehensive understanding of global regulatory expectations and contribute to regulatory documents and interactions with agencies.

The Associate Principal Scientist is a skilled modeler and a quantitative drug developer, with a strong, integrated understanding of the strategic elements of drug discovery and development and leads the QP2 strategic, executional and operational efforts on a team. The ideal candidate is collaborative, possesses a learning mindset and can work through scientific challenges within and between departments to develop aligned strategies and solutions. In addition, you share your skills and ideas with junior scientists and with the broader QP2 department to advance our science. Excellent communication skills are required including the ability to clearly present scientific data in group settings.

Within QP2, you have a unique opportunity to accelerate your professional career as a quantitative drug developer taking advantage of our end-to-end pipeline support in one of the world’s most research-intensive biopharmaceutical companies.

Required:

• A Ph.D. or equivalent degree with at least 3 years of experience - OR- a PharmD or equivalent degree with at least 5 years of experience - OR- a MS or equivalent degree with at least 7 years of experience, where “experience” means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia
• An educational background in PK/PD, pharmaceutical sciences, pharmacometrics, mathematics, statistics/ biostatistics, computational biology/chemistry, or chemical/biomedical engineering.
• Experience in performing population PK / PKPD analyses using standard pharmacometric software (e.g. NONMEM, Monolix, Phoenix, R, Matlab)
• Proficiency in written and verbal communication and interdisciplinary collaboration

Preferred:

• An exemplary record of increasing responsibility, independence, and demonstrated impact in driving drug development decisions through application of model-based approaches
• Knowledge of cardiometabolic, ophthalmic or immunologic disorders
• Skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics
• Scientific understanding of ADME and biopharmaceutic properties of biologics, small molecules, or non-traditional therapeutics
• Demonstrated ability to participate in and to lead an interdisciplinary team

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R166272