Postdoctoral Research Fellow - VHH Sequence Optimization
Be a part of the legacy: Postdoctoral Research Fellow Program
Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
We are seeking a talented and motivated Postdoctoral Scientist with expertise in biochemistry and a strong interest for protein/antibody modeling and in-silico predictive approaches to join the Protein Purification and Analytical Characterization group part of the Protein Sciences Department at the company's Discovery Biologics site in South San Francisco. The successful candidate will develop a high throughput analytical characterization platform to understand key sequence attributes which are impactful for the developability of single-domain antibodies (VHHs). This large dataset will shed light on key biophysical properties which are important for optimal developability of this new biologics modality. The postdoctoral fellow will work in close collaboration with data Scientists at our company to use the data generated to develop, train and validate in-silico developability sequence-based prediction tools and machine learning algorithms. The candidates should have strong and documented expertise in protein purification using atmospheric and FPLC based purification methods and chromatographic supports and analytical characterization methods including but not limited to: UP-SEC, Reverse Phase (RP), thermal and chemical stability assessments (Nano-DSF), DLS, capillary electrophoresis etc.
Responsibilities include but are not limited to:
Express and purify large numbers of VHH molecules
Analyze generated molecules using current biophysiochemical characterization methods
Develop and implement new characterization methods as needed
Review data and use statistical analysis approaches to identify patterns and correlations
Actively participate to the design of new variants of VHHs based on learnings from previous rounds of purification, analytical characterization and statistical analysis outcomes
Actively participate in the development, training and validation of in-silico developability sequence-based prediction tools and machine learning algorithms
Actively participate in the lab life and maintain needed lab equipment
Comply with company data retention and lab safety policies and procedures
Complete required trainings
Attend and actively participate in department and group meetings
Attend and actively participate to our company and external scientific symposiums and meetings/seminars
Write and review publications and manuscripts
Education Minimum Requirement:
Candidates must currently hold a PhD OR receive a PhD in biochemistry, biologics, engineering (structural) .
Required Experience and Skills:
Strong expertise in biochemistry and molecular biology techniques and methods
Protein expression using CHO, HEK and E. coli systems
Protein purification including atmospheric and FPLC based approaches (AKTA systems preferred)
Protein analytical characterization such as UP-SEC, RP, DLS, CE-SDS, Nano-DSF etc.
Basic statistical analysis
High attention to detail and scientific and technical problem solving
Must have strong organizational skills to deal with large amounts of data
The candidate should exhibit excellent communication and collaborative skills for working on cross-functional multi-disciplinary teams
Preferred Experience and Skills:
Previous experience working with VHHs preferred
Antibody/ VHHs biochemistry experience preferred
Protein/Antibody in-silico structure modeling experience is a plus
Initial machine learning and in-silico predictive sciences experience preferred
Previous experience with high throughput technologies and methods for antibody/ VHHs analytical characterization is preferred
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.
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In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
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Expected salary range:$0.00 - $0.00
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