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Merck & Co, Inc

Postdoctoral Research Fellow--Ultra-high Throughput Mass Spectrometry (uHT-MS) ( MERCUSR151827ENUS)

Science and Research

Biological Research



Rahway, New Jersey, United States

Job Description

Understanding and exploiting the capabilities of ultra-high throughput mass spectrometry (uHT-MS)

New hires working in our US & Puerto Rico locations will be required to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement, subject to applicable law.

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview:

We are seeking a talented and motivated Postdoctoral Scientist passionate about the application of the latest analytical technologies within pharmaceutical drug discovery. Working within the Bioanalytics Department in Pre-Clinical Development (PCD), you will be building a foundational understanding of Acoustic Ejection-Mass Spectrometry (AE-MS). AE-MS brings data acquisition times down by 10-100x or more compared with traditional discovery high throughput quantitative LC-MS/MS approaches opening up possibilities of redefining not just bioanalytical strategy, but also how experiments are designed and executed. Based in New Jersey, you will have access to a laboratory containing production, preproduction and research grade AE-MS instrumentation. Taking the foundational knowledge you build, you will be working with cross-functional teams and take part of a research collaboration with the instrument vendor to define strategies for rapid AE-MS method development. You will apply this to the development of new workflows within Drug Metabolism and Pharmacokinetics (DMPK) and evaluate the potential for the technology in the real-time analysis of kinetic experiments related to Drug-Drug Interaction (DDI).

Responsibilities include but are not limited to:

  • Design and execution of experiments to build Structure Activity Relationship for mass spectrometry ionization efficiency. You will work with chemistry, automation and compound logistics, bioanalytics and data science teams.

  • Develop a strategy for rapid AE-MS method optimization and apply it to a real-world bioanalytical application in DMPK.

  • Develop an understanding for application of AE-MS in real-time analysis of enzyme kinetic experiments.

  • Continue to build upon our company's research collaboration with the instrument vendor.

  • Actively engage in the education and training of our company's colleagues.

  • Write, publish and present (internally and externally) findings.

Education Minimum Requirement:

  • Candidates must currently hold a PhD OR receive a PhD by Fall 2022 in Chemical, Analytical/ Bioanalytical or Biological Sciences.

Required Experience and Skills:

  • Mass Spectrometry

  • Analytical/Bioanalytical Science

  • Basic statistical analysis and data handling skills

  • Must have strong organizational skills to deal with large amounts of data

  • High attention to detail; scientific and technical problem-solving

  • The candidate must exhibit excellent communication and collaborative skills for working in cross-functional multi-disciplinary teams

Preferred Experience and Skills:

  • Design of Experiments (DoE) experience

  • Previous experience with high throughput technologies and laboratory automation

  • Data science and programming (R, Python, etc.)

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.


Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R151827