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Job Details

Merck & Co, Inc

Postdoctoral Research Fellow--Chemical Crystallography ( MERCUSR161638ENUS)

Science and Research

Biological Research



Rahway, New Jersey, United States

Job Description

New hires based in the US & Puerto Rico will be required to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement, subject to applicable law.

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview:

We are seeking a highly driven and motivated postdoctoral research fellow to join the Materials & Biophysical Characterization group within Analytical Research & Development. This individual should be passionate about chemical crystallography, with an interest in developing a supramolecular toolkit for molecular structure determination. Their project will involve the utilization of porous organic frameworks for the encapsulation of target molecules with the goal of molecular structure determination by X-ray diffraction. The encapsulation technologies will deliver innovative and convenient methods for structure determination for molecules that otherwise cannot be crystallized, including precise stereochemical assignment. The successful candidate would explore the use of encapsulation methodologies to develop a workflow targeting small molecules.

Responsibilities include but are not limited to:

  • Crystallization and encapsulation of small molecules within porous organic frameworks.

  • Growing single crystals and solving structures from X-ray diffraction experiments.

  • Troubleshoot and maintain instrumentation as needed.

  • Collaborate closely with external academic institutions and partners.

  • Leverage traditional and advanced physical characterization techniques to rapidly assess guest encapsulation prior to structure elucidation.

  • Interpret and present data to internal and external partners.

  • Collaborate effectively with cross-functional and technical experts to facilitate scientific success.

  • Publish research in peer-reviewed journals and present work at scientific meetings.

  • Ensure that safe laboratory practices are followed.

Education Minimum Requirement:

  • Candidates must currently hold a PhD OR receive a PhD by Fall 2022. Preferred educational background includes but is not restricted to Chemical Engineering, Chemistry, Materials Science, Pharmaceutics, Physical Chemistry, or related field.

Required Experience and Skills:

  • X-ray crystallography experience.

  • Familiarity with refinement software packages, such as ShelX, OLEX2, etc.

  • Experience with growing single crystals and crystallization.

  • Proven ability to independently design and execute experiments, interpret data, and identify appropriate follow-up studies.

  • Track record of adaptability, creativity, critical thinking, innovation, integrity, and teamwork.

  • Strong attention to detail with the ability to multi-task and handle multiple responsibilities simultaneously.

  • Strong track record of scientific achievement (publications, patent, etc.) and effective writing skills.

Preferred Experience and Skills:

  • Experience with porous organic frameworks including metal organic framework, hydrogen-bonded organic framework, covalent organic framework, etc.

  • Benchtop synthetic experience.

  • Ability to work in a multidisciplinary team environment with a strong communication skills.

  • Strong record of publications in peer-reviewed journals.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.


Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

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US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

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Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:




VISA Sponsorship:


Travel Requirements:

No Travel Required

Flexible Work Arrangements:

Not Specified


Not Indicated

Valid Driving License:


Hazardous Material(s):

Number of Openings:


Requisition ID:R161638