Postdoctoral Fellow, Protein & Structural Chemistry
Be a part of the legacy: Postdoctoral Research Fellow Program
Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
The Department of Protein & Structural Chemistry within our company Research Labs (South San Francisco) is seeking a motivated Postdoctoral Fellow with expertise in protein biochemistry and structural biology and a strong interest structure-based drug discovery. The successful candidate will use a combination of biophysical and structural techniques, including X-ray crystallography and cryo-electron tomography, to study various aspects of antibody-drug conjugate (ADC) developability.
The postdoctoral fellow will work in close collaboration with biochemists, biophysicists, chemists, and protein modelers across the our company network to execute an ambitious proposal. These collaborative interactions will require moderate travel between sites to maximize in-person training and leverage different available capabilities. Promising prospective candidates that do not meet all of the required experience/skills outlined below are nonetheless encouraged to apply. Training and mentoring will be provided for all aspects of the tenure, and will be provided at multiple sites.
Training and Responsibilities include:
Expression and purification of monoclonal antibodies.
Chemical conjugation of antibodies and linker/payloads.
Biophysical characterization of biologics targets.
Structural characterization of recombinant proteins by X-ray crystallography and/or cryo-EM.
Cryo-electron tomography (cryo-ET) of proteins in their native environment.
Sharing of knowledge through attending internal and external scientific conferences.
Write and submit publications to peer-reviewed journals.
Education Minimum Requirement:
Candidates must hold a PhD or will you have completed your PhD within the next year in structural biology, biochemistry, biophysics, or related field.
Required Experience and Skills**:
PhD degree in structural biology or related field.
Demonstrated experience in a broad range of activities for x-ray crystallography and/or atomic resolution single particle cryo-EM, including sample preparation, data collection, image processing & structure determination.
Excellent communication skills (written, presentation, and oral).
Ability to work effectively and flexibly within timelines
Ability to manage a multifacted project
Demonstrated ability to prepare peer-reviewed publications
Intended training and mentoring in one or more of the following fields during the Post-doc:
Biophysical and functional characterization methods (e.g. DSF, HDX, SAXS).
Structure determination of small molecule protein complexes.
Using computational tools for protein engineering and design.
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.
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In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
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