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Job Details

Merck & Co, Inc

Postdoctoral Research Fellow: Pharmacokinetics, Pharmacodynamics and Drug Metabolism

Science and Research

Research and Development


South San Francisco, California, United States

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for postdoctoral researchers that is designed with an academic focus in an industrial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

At South San Francisco, our new multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with our company's world-class Research & Development expertise in small molecules.

Position Overview:

We are seeking a postdoctoral research fellow that is passionate about working collaboratively across the company's scientific network, geographical sites, and departments, particularly from the the department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism and sub-department groups that include Bioanalytical, Absorption, Distribution, Metabolism, Excretion & Discovery Toxicology, and Quantitative Pharmacology & Pharmacometrics groups to advance our translational science capabilities to better understand the potential for drug-drug interactions in patients with dyslipidemia, hypertension, and/or diabetes. Role includes design, coordination, and interpretation of preclinical pharmacokinetic experiments in various wide-ranging disease models to generate drug-drug interactions data and to compare those data to patients’ data to establish correlations. To establish those correlations, the fellow will gain experience with software tools of the trade such as WinNonlin and R. Further, data from wide-ranging preclinical model and clinical patient data, by accessing databases and literature, will be utilized to build physiological-based pharmacokinetic models to harness all data and predict future drug-drug interactions risk. A strong focus will be scientific and professional development, as well as publication. The position is intended to last 2–3 years.

Responsibilities include but are not limited to:

  • Work in a highly collaborative and dynamic environment with a multifunctional team of scientists

  • Design, coordinate, analyze, and summarize data from pharmacokinetic experiments in wide-ranging preclinical models.

  • Utilize model data to compose physiological-based pharmacokinetic models to predict human drug-drug interactions risk

  • Communicate results via presentation to internal teams, external presentations, and publication

Education Minimum Requirement:

  • Candidates must currently hold a PhD or will you have completed your PhD within the next year, in biochemistry, pharmacology, chemistry, or related field.

Required Experience and Skills:

  • Passionate about science and excited to learn new things

  • Scientific understanding of biopharmaceutical and Absorption, Distribution, Metabolism, Excretion properties of small molecules

  • Proficiency in written and verbal communication, interdisciplinary collaboration, and problem scoping and planning

  • Skills in experimental design, mathematical problem solving, critical data analysis /interpretation

Preferred Experience and Skills:

  • Competency in physiological-based pharmacokinetic modeling software (Simcyp, Gastroplus, Phoenix WinNonlin, R or equivalent)

  • Strong understanding of pharmacokinetic drug-drug interactions

  • Familiarity with preclinical pharmacokinetic study design, analysis, and interpretation

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.


Who we are …

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your Human Resource Business Partner or Talent Acquisition Advisor.


Post Doc:

Under New York City, Washington State and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected salary range:


Available benefits include bonus eligibility, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. For Washington State Jobs, a summary of benefits is listed here.

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Know Your Rights

EEOC GINA Supplement​

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here to request this role’s pay range.

Learn more about your rights, including under California, Colorado and other US State Acts

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:




VISA Sponsorship:


Travel Requirements:


Flexible Work Arrangements:

Flex Time, Remote Work


Not Indicated

Valid Driving License:


Hazardous Material(s):

Requisition ID:R164098