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Job Details

Bristol Myers Squibb

Principal Scientist, Sequencing Research and Genomics (R1559599-en-us)

Science and Research

Research and Development



San Diego, California, United States

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Position Summary

We are seeking a talented and highly motivated research scientist to join our Sequencing Research and Genomics (SRG) team in San Diego. The SRG team establishes integrated, innovative NGS capabilities across BMS Research and Early Development (R&ED) and enables and enhances drug discovery and clinical translation for patients through close collaborations. Work performed will contribute to therapeutic discovery and early translational research programs in oncology, autoimmune, cardiovascular, and neurological indications.

The successful candidate will be responsible for developing and deploying novel -omics technologies to elucidate disease and therapeutic mechanisms during the early stages of drug discovery. The role will involve close partnership with scientists from BMS R&ED to drive new experimental and data analysis strategies. This will include inter-disciplinary collaborations with experimental biology and computational genomics research colleagues to derive deep and robust insights from diverse genomics assays. The principal scientist will have the opportunity to develop novel NGS-based assays in areas such as single cell multi-omics, epigenomics, spatial transcriptomics, cell free nucleic acid techniques, and CRISPR-based screens. This position is ideal for someone with demonstrated scientific expertise, a team player with a collaborative spirit, the ability to manage multiple projects while prioritizing tasks towards completion, and excellent communication skills.

Key Responsibilities

  • Collaboratively design and execute NGS profiling experiments to elucidate mechanisms key to disease state, identify and validate putative therapeutic targets, and support pre-clinical therapeutic response biomarker hypotheses using pre-clinical disease models and patient samples.
  • Innovative research at the leading edge of NGS sample and library preparation technologies, including implementation of novel protocols that are drawn from literature, academic and in-house collaborators, and are aligned to scientific research objectives.
  • Advise on sample extraction, library preparation and QC, guide collection of supporting metadata, liaise with computational research colleagues during analytical research, and early-stage discovery as well as translational scientists.
  • Design and perform pilot experiments to test new protocols and assess new profiling platforms and external vendor capabilities.
  • Contribute to the operation of internal next-generation sequencing resources and development of supporting infrastructures, including documentation of protocols developed, and supervision of technical support staff as required.
  • Present strategies, approaches, results, and conclusions to BMS colleagues and external audiences to a publishable standard.
  • Contribute to enable strategic collaborations with academic and commercial collaborators to benefit therapeutic programs.

Qualifications & Experience

  • Ph.D. or equivalent in biology, genetics, biomedical engineering, or related discipline at a recognized higher-education establishment
  • At least 5 years of interdisciplinary research experience with focus on cell or molecular profiling for elucidation of human disease in academic or biopharmaceutical research scenarios.
  • Expertise in performing state of the art NGS and single-cell profiling studies with demonstrable record of innovative protocol development and peer-reviewed publication in relevant areas.
  • Experience in the use of NGS profiling methods to answer complex research questions in cancer biology, autoimmune disease, epigenetics and/or immune biology is preferred.
  • Hands-on experience of sample and library preparation, as well as operation and maintenance of high- and low-throughput NGS apparatus (Illumina preferable).
  • Experience in using complementary cell profiling platforms, e.g., flow cytometry, PDX models is preferred.
  • In-depth knowledge in advanced NGS technologies and experimental design considerations, and familiarity with downstream bioinformatics approaches applied to process, analyze, visualize, and interpret NGS datasets.
  • Awareness of contemporary LIMS schema, open-source bioinformatics tools and database structures.
  • Experience in performing functional assays to validate experimental findings.
  • Excellent time management and organizational skills, proven problem-solving skills, collaborative nature, and adaptability across disciplines
  • Excellent verbal and written communication skills. Fluent verbal and written English language skills prerequisite.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.