Postdoctoral Research Fellow: Quantitative Pharmacology and Pharmacometrics

Job Description

New hires working in our US & Puerto Rico locations will be required to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement, subject to applicable law.

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview:

The Quantitative Pharmacology and Pharmacometrics (QP2) Department of our company's Research Laboratories in West Point, Pennsylvania / Rahway, New Jersey is seeking a curious and collaborative Postdoctoral Scientist with a strong interest to develop quantitative models of biological systems. The successful candidate is eager to learn and not intimidated by tough scientific challenges. You will build a mechanistic mathematical model based on publicly available information that integrates key pharmacological and physiological pathways to quantitatively understand the interplay among pathways involved in different aspects of non-alcoholic steatohepatitis (NASH) pathogenesis. Such a model enables prioritization of potential NASH drugs with different modes of action based on projected clinical benefit and provide means to explore favorable drug combinations. Furthermore, it could be used to explore the impact of different background therapies in clinical NASH trials. The postdoctoral scientist will have the opportunity to work in collaboration with data scientists and modelers, biologists and clinicians at our company's laboratories.

Responsibilities include but are not limited to:

• Develop a quantitative systems pharmacology (QSP) model of key pathways in NASH
• Conduct literature searches to inform key pathways and identify relationships between components in the model
• Qualify the model with existing clinical data
• Perform simulations and sensitivity analyses
• Collaborate across the scientific network within our company's laboratories
• Invest in your professional and scientific development
• Attend and actively participate to our company and external scientific symposiums and meetings/seminars
• Write and review publications and manuscripts

Education Minimum Requirement:

• Candidates must currently hold a PhD OR will receive a PhD by Fall 2022.

Required Experience and Skills:

• A strong passion for science and exited to learn new things
• An educational background in PK/PD, pharmaceutical sciences, pharmacometrics, mathematics, data science, statistics/ biostatistics, computational biology/chemistry, or chemical/biomedical engineering
• Mathematical [or mechanistic] modeling of biological systems using R, Matlab, or other similar programing language
• Proficiency in written and verbal communication

Preferred Experience and Skills:

• Knowledge of NAFLD/NASH or other cardiometabolic diseases
• Experience with software as Simbiology (Matlab), Berkeley Madonna or others
• Skills in experimental design, mathematical problem solving, critical data analysis/interpretation, or statistics
• Experience with machine learning

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

MRLpostdoc

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

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PDA

New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

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Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here to request this role’s pay range.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:

Requisition ID:R155855