Job was saved successfully.
Job was removed from Saved Jobs.

Job Details

Bristol Myers Squibb

Principal Scientist Translational Research (R1554453-en-us)

Science and Research




Brisbane, California, United States

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Responsibilities will include, but are not limited to, the following:

  • Being a thought leader within the team to critically evaluate the literature regarding target and disease biology
  • Develop pre-clinical program-specific translational strategy/plans focusing on target engagement, pharmacodynamics, patient stratification biomarkers, mechanism of action (MOA) studies and build reverse translation database
  • Work in a highly matrixed environment and efficiently collaborating with discovery scientists, clinical research physicians, clinical biomarker leaders, statisticians, computational biologists, translational scientists
  • Integrate input from project teams to select, develop, and validate biomarker assays for clinical implementation
  • Work independently to design, execute, interpret and document biomarker experiments to support Translational Research and Early Development projects. Identify and collaborate in disease or therapeutic area-specific academic/industry partnerships and consortia, with the goal of advancing scientific understanding of disease pathophysiology to enable early target and biomarker identification and validation
  • Participates in evaluation of CROs for sample and data analysis and delivery capabilities, as needed
  • Participate in Prognostic Diagnosis (PDx) biomarker assay development through internal and external collaborations
  • Keep up-to-date on relevant scientific/technical literature in order to applying external knowledge to internal Translational Research programs as appropriate
  • Prepares and delivers internal and external presentations, publications
  • Stay in compliance with BMS core behaviors and Brisbane local site guidance, e.g., safety, etc.

Skills/Knowledge Required

  • PhD, MD or equivalent degree, preferred postdoc experience
  • At least 5 years of work experience, preferably within the Pharmaceutical/Biotechnology industry
  • Preferred experience in Cardiovascular Biology & Translational Research
  • Strong background and expertise in heart failure and cardiomyopathy highly preferred
  • Understanding of drug discovery and development, especially transition from pre-clinical to clinical stage of development
  • Proven scientific/leadership expertise (working in teams, mentoring people, managing projects)
  • Excellent record of performance and scientific accomplishments as demonstrated by impactful contributions to the scientific community, pipeline contributions, peer reviewed publications and patent applications highly desired
  • Familiar with RNA/DNA/protein-based Translational biomarker technologies: RNASeq, scRNASeq, RNAScope, qPCR, multiplex cytokine/chemokine analysis, proteomics, whole blood flow cytometry analysis, in vitro cell-based assays, ELISA, MSD, western blots, etc.
  • Experience in mining of large datasets, either independently or in collaboration with bioinformaticians to understand disease pathophysiology and/or establish patient segmentation hypotheses
  • The ability to support multiple projects in a fast pace and collaborative environment
  • Excellent organizational, written and verbal communication skills; prepares and delivers presentations within the department, to governance and senior leadership bodies, and externally
  • Experience in managing external collaborations with KOLs from academic institutions and CROs and setting clear timelines and expectations
  • Recognizes cross-functional issues and communicates within the larger organization. Provides expert guidance to multi-disciplinary teams and senior management.
  • Has a track record of delivering results, driving continuous improvements, and building effective cross-functional networks.
  • Knowledge of supervision and development of scientific employees. Skilled in applying that knowledge to optimize the performance of those supervised.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.