Senior Scientist, Stromal / Vascular Biology (R1553095-en-us)
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The Tumor Microenvironment Thematic Research Center (TME TRC) at Bristol Myers Squibb is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology with the goal of enhancing responsiveness to immune checkpoint blockade, targeted and cell therapies. Comprised of scientists across multiple disciplines, we are responsible for the biology and translational science required to support drug development from target identification through first-in-human studies.
We are seeking a highly motivated and experienced Senior Scientist with oncology drug discovery and development experience to join the Stromal Biology team as part of the Immunology and Stromal Biology Discovery group within the TME TRC (Redwood City, CA). The individual will drive early drug discovery programs across both large and small molecules from target identification through target validation and lead optimization and, ultimately, toward clinical proof of concept in patients. The individual will work collaboratively with drug discovery, predictive science, translational and clinical teams to advance molecules and build a deeper understanding of the role for stromal/vascular biology in the TME. The qualified candidate will bring extensive knowledge in oncology, drug development, stromal and/or endothelial biology to the team.
Biology Program Lead for endothelial/vascular discovery portfolio projects across large and small molecule therapeutic modalities
Design and execution of robust preclinical data packages to support drug discovery programs
Contribution to exploratory target identification and validation of novel targets
Participation in review of external/business development opportunities
Biology discovery support for vascular facing clinical assets
Opportunities to formulate and guide strategies for endothelial targeting in the TME
PhD with 2+ years of relevant experience, M.S. with 8-10 years of relevant industry experience, or B.S. with 12-15 years of relevant industry experience
Proven track record in cancer biology, immuno-oncology, and/or stromal/vascular/endothelial biology demonstrated by academic and/or patent publications
Strong background in biologics and/or small molecule drug discovery, including the ability to design and execute a strategy to validate and optimize drug candidates
Knowledge of in vivo or in vitro preclinical models to assess endothelial biology and its contribution to oncology or immunology is highly desirable
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
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