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Job Details

Bristol Myers Squibb

Senior Manager, Senior Principal Scientist, Product Sciences (R1546185-en-us)

Science and Research




Warren, New Jersey, United States

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Cell Therapy is one of the most groundbreaking new forms of cancer treatments being studied today. With therapies only in their infancy and BMS’s continued investment in our Cell Therapy capabilities, the growth potential of this science, your career, and the ability to help patients are incredible.

As part of the Product Sciences group, the energetic and motivated Sr. Principal Scientist will have responsibility for leading the development of scientific strategy that informs the design, execution, and interpretation of complex experiments/studies related to generation of new/enhanced knowledge regarding cellular immuno-oncology-based products, intermediates, starting materials, manufacturing processes and analytical tools within a CMC technical development function. The Sr. Principal Scientist will be tasked to independently drive achievement of program, platform, and functional objectives in collaboration within technical development teams and across the cell therapy franchise, including active engagement with clinical development, research and translation development, informatics, and biostatistics organizations. To achieve these objectives, the Sr. Principal Scientist will be expected to behave as a servant-leader that seeks to develop, grow, and empower a talented teamed composed of scientists at varying levels of experience.

Responsibilities will include, but are not limited to, the following:

  • Drive development of integrated scientific/technical strategy to inform the development of biological hypotheses relating to product cellular attributes and their impact on clinical outcomes, manufacturing, and development of analytical tools
  • Lead teams responsible for technical development of sensitive bioanalytical assays to characterize cell products, intermediates and starting material
  • Build cross-functional collaboration to develop and execute complex characterization strategies relating to clinical and non-clinical product development
  • Expand framework to enable/enhance utilization and value capture of data via informatics-based correlative studies supporting knowledge building across the technical development portfolio
  • Support CMC objectives by providing biological and technical knowledge across program and platform strategies for product, process, and analytical development
  • Efficiently organize data, integrate concepts, and share within, across teams with appropriate level of complexity/details based on audience
  • Proactively support expansion of general knowledge within cell therapy development function and maintain awareness of competitive landscape in the cellular immuno-oncology space
  • Actively engage in the development, growth, career planning, and empowerment of individuals and teams through deliberate and thoughtful strategies and work to provide an optimal environment within which teams and individuals can flourish
  • Reinforce safe workplace practices in accordance with company and OSHA policies/procedures

Skills/Knowledge Required:

  • Ph.D. or M.S. in Immunology, Cell/Molecular Biology, Biomedical Engineering, or related discipline with demonstrated track/record of experience leading teams to achieve objectives in academic and/or industrial settings (5-10 years for Ph.D./ 10+ years for M.S.)
  • Demonstrated ability to successfully lead functional and matrix teams towards achieving objectives and deliverables on time with high quality
  • Strong desire to work within a team structure and to develop, mentor and coach team members leading to their operational success, engagement, growth, and development is required
  • Ability to work under minimal technical supervision, perform technical, strategic, and operational tasks independently and lead complex and cross-functional activities
  • Ability/willingness to identify and surface both risk and opportunity
  • Extensive experience in mammalian cell culture techniques, including isolation of immune cell subsets, maintenance and expansion of primary cells and cell lines is required
  • Advanced knowledge of basic techniques in immunology, cell biology and molecular biology is required. Experience with FACS, immunofluorescence-based assays, ELISA, PCR, cytokine and chemokine detection, cell-based bioassays is highly desired
  • Experience with analytical method development for a variety of cell-based bioassays, binding assays and/or residual impurities assays is preferred
  • Motivation and drive to acquire new skills and knowledge is desired
  • Willingness to work in a regulated industrial environment.
  • Excellent verbal and written communication skills

If you want to challenge yourself, accelerate your career, and give new hope to patients, there’s no better place than here with our Cell Therapy team. Full of incredible and dedicated team members, those working on CAR-T and other forms of Cell Therapy are transforming patients’ lives through science. From studying individualized cell lines to making brand new discoveries, this bold and personal discipline allows you to grow your career while making a lasting impact on the field of medicine. Join us today.


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.