Senior Principal Scientist, Neuroscience

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Neuroscience TRC is committed to development of transformational therapeutics for patients with neurodegenerative and neuromuscular diseases. We have built a network of external partnerships across multiple treatment modalities (small molecules, biologics and RNA targeting) that leverage our leadership in protein homeostasis and inflammation to attack neurological diseases. Internal research focuses on protein homeostasis by direct and ligand directed degradation, neuroinflammation and remyelination.

Areas of interest include, but are not limited to, the following approaches:

Disease modifying therapies for neurodegenerative, neuro-inflammatory and neuromuscular diseases; CNS targets that modulate protein homeostasis, protein clearance, inflammation and reduce or eliminate toxic protein production; Emerging technologies (RNA, DNA targeting, gene regulation, editing and replacement, vector optimization) that when matched to underlying disease genetics can deliver a precision medicine portfolio with a high probability of success to address unmet medical needs; Targets in orphan/rare neurological and neuromuscular diseases. AI/ML in target identification and neurology drug discovery; Translational tools and technologies such as neuroimaging and fluid biomarkers to track neurodegenerative disease; Novel blood brain-barrier delivery technologies.

Position Summary:

This opening for a Senior Principal Scientist is for a laboratory-based, integral member of the Neuroscience Thematic Research Center (TRC) who can use their neuroimmunology expertise to lead research projects as well as contribute to the clinical transition of new drug candidates for a broad range of neurodegenerative indications. The successful applicant will leverage their experience in neuroinflammation/immunology and in vitro/ex vivo studies with sophisticated lab techniques for biomarker detection and assessment to work collaboratively across disciplines (eg, in vivo) to pharmacologically characterize target engagement and efficacy in relevant models. This position offers great potential for continued growth with exposure to all aspects of disease modelling and drug development, including in vivo studies. The Senior Principal Scientist will also be in a position to offer training and oversight to junior team members while participating in project teams and contributing to regulatory submissions.

Major Responsibilities:

• Implementation and validation of assay systems in ex vivo samples and/or cell types to screen and characterize the pharmacological responses to modulation with small molecules, antibodies etc.

• Development of assays with readouts that are translationally-relevant to the neurodegenerative indications

• Ability to develop assays for in vivo target engagement assessment

• Identification and assessment of potential new Neuroscience-focused targets

• Ability to create new research plans and to present at project team and departmental meetings

• Ability to actively participate in and oversee outsourced projects/collaborations

• Creation and interpretation of scientific documents including study protocols and study reports suitable for regulatory submission

• Mentorship of junior team members

• Generate, record and report raw data and interpret to refine the next steps

• Ensure the proper documentation of all data in electronic notebooks

• Ability to analyze complex data using software tools and appropriate statistical analyses and make a concise graphic presentations.

• Other responsibilities as assigned

Knowledge, Skills and Abilities Required:

• Ph.D. in Biology, Neuroscience, Immunology (or similar field) and 10+ years of post-doctoral research experience, preferably with at least 5+ years of industry experience

• Supervisory experience is considered advantageous

• Flow cytometry and application of neuroimmunology expertise

• Demonstrated history of applying a broad variety of in vitro/ex vivo laboratory skills to drive progress in a variety of projects

• Experience with iPSC microglia/astrocytes

• Data interpretation and application to the design and optimization of follow-on studies

• Capable of working within a fast-paced team environment that contributes to multiple projects at any given time

• Ability to work independently as well as collaboratively, both within the immediate research team and across company sites and functions

• Excellent organizational, record keeping, plus oral and written communication skills

• Motivated and detail-oriented with a strong interest in driving productivity in clinically-directed research

• Skilled in using standard software as well as specialist equipment, graphing and statistical analysis software

• Positively contribute to a work environment that fosters professionalism, mutual respect, teamwork, output and collaboration

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Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

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