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Job Details

Bristol Myers Squibb

Senior Principal Scientist, Hematology - Myeloid, Translational Medicine

Science and Research



Summit, New Jersey, United States

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Hematology Translational Medicine Disease Team at BMS

Translational Medicine is part of the Global Research and Early Development organization in BMS and leads mid to late stage clinical, pharmacological, and translational research and development activities for the BMS hematology pipeline and supports late-stage portfolio for translational development and life cycle management. Translational Medicine Hematology at BMS has a long-standing history of scientific rigor as evidenced by our peer-reviewed publications, delivery of drug approvals including Revlimid, Pomalyst, Idhifa, Inrebic, Reblozyl, Vidaza and Onureg, strong academic collaborations and talent development. Our areas of focus include but are not limited to Multiple Myeloma, Acute Myeloid Leukemia/MDS, Lymphoma and Erythroid disorders. This group integrates scientific learnings from the lab and clinic as well as business insights of multiple functions and leads the development of translational strategies at the franchise level.

Reporting to the Director, Hematology Translational Medicine, the role will be responsible for development and execution of drug and lymphoid/myeloid disease-centric translational strategies in hematology for assigned asset programs. Key responsibilities of this role are to act as hematology asset lead scientist to deliver biomarker strategies for clinical programs, disease strategies for high-risk unmet need, patient selection, combination strategies and life-cycle management of our pipeline as well as regulatory support including pre-clinical and translational sections of NDA submissions. This individual will work on cross-functional project teams to drive execution of translational/biomarker plans working with laboratory scientists and BMS members from clinical, commercial, regulatory, medical affairs and diagnostics as well as engage external academic collaborators/Key opinion leaders (KOLs).

Technical Skills:

  • In-depth understanding of cancer biology/hematology, knowledge of clinical landscape, evolving therapies, competitive scenarios.
  • Strong understanding of clinical, translational, and mechanistic data interpretation.
  • Understanding of early or late-stage drug and translational development process; including clinical trial experience in industry or academia
  • Experience in protocol authoring and informed consent form (ICF) review.
  • Working knowledge of technological platforms covering biomarker measures including but not limited to genomics, immune profiling etc.
  • Proven ability to work with global disease teams to develop strategies to support drug life cycle management
  • Strong verbal and written communication skills with experience in developing written documents such as primary manuscripts/publications/reviews, disease strategies, mechanism slides, regulatory submissions, literature/ patient segment analyses
  • Proven scientific/project leadership expertise (working in teams, managing people/projects)
  • Ability to synthesize complex scientific and business problems into strategy
  • Basic understanding of intellectual property, contracting terms and provisions


  • Leads the development of asset specific translational goals and objectives for the Hematology Translational Medicine group (for internal /external, translational collaboration, compound specific plans etc.),
  • Represents Translational Medicine (TM) on cross-functional Strategy and Global Project Teams
  • Supports regulatory submissions, regulatory interactions, writes translational sections for regulatory response and answers to regulatory queries for the TM group
  • Communicates regularly, prepares, and presents within the department/externally as required
  • Participates in translational research with the Hematology Laboratory
  • Oversees biomarker plan development and execution in clinical trials, large genomic projects from human clinical samples, and clinical trial support (defined clinical experiments from the development teams). This includes development of high dimensional bioinformatics in collaboration with the Informatics and Predictive Sciences group
  • Responsible for selection and delivery of Clinical PD or Biomarker assays, translated from discovery (if applicable or appropriate) or developed specifically for early clinical use, assessing feasibility and applicability for companion diagnostics
  • Application of model systems (in collaboration with the disease biology and in vivo pharmacology groups) beyond those routinely employed by discovery teams that aid in patient stratification/response, dose optimization and therapeutic use, either in-house or through external collaborations
  • May participate in BD and established teams to evaluate the potential in-licensing opportunities that will advance our Drug Discovery and Development pipeline
  • May perform advisory and mentoring role for junior scientists
  • Participate or present at scientific advisory boards to support drug programs/projects
  • Assists in developing and maintaining group budget and workforce plan


  • PhD in Hematology/Oncology or related field with min 6-8 years in industry and academic setting
  • Strong track record in large and small biotech/pharmaceutical companies, leading translational/biomarker studies, or innovative efforts to deploy technologies and assays for enhanced translational capabilities or similar skill sets in academia
  • Proven track record of success in drug discovery and development
  • Experience with translational/biomarker strategies for early or late-stage clinical trials or investigator sponsored trials in academia
  • Competence in analysis and solving of problems, and the ability to prioritize to achieve goals.
  • Excellent communication, managerial and scientific qualities are expected

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

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