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Bristol Myers Squibb

Scientist Genetic Cardiomyopathy Biology (R1556809-en-us)

Science and Research

Scientist

Yearly

No

Brisbane, California, United States

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Scientist Genetic Cardiomyopathy Biology

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology, and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

SUMMARY:

BMS seeks a highly motivated, creative and collaborative Cardiovascular Biologist with Cell Signaling or Molecular Biology focus to support research efforts to identify and characterize novel therapeutic targets for inherited cardiomyopathy and support mechanism-based drug development. The successful candidate will work collaboratively with teams in Molecular Biology, Sarcomere Biology, and Pharmacology to support BMS’s Cardiovascular Research and Early Discovery efforts. Research will be aimed at the identification and characterization of novel therapeutic targets, support of compound screening efforts, and translational work to fully characterize our drug candidates. The applicant is required to have a strong background in molecular pathogenesis of heart diseases, protein-protein interaction, intracellular transport, manipulating gene expression and evaluating changes in gene-expression. This position provides an exciting opportunity to be a part of and grow with a new core function within the GCM Biology Department.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

  • Conducting scientific research to understand the molecular pathogenesis of heart failure and define new therapeutic targets
  • Working with minimal guidance and in collaboration with different functional groups to advance state-of-the art techniques at the molecular level of research
  • Communicating and collaborating with members of project teams in the execution of laboratory experimentation
  • Maintaining working knowledge of principles and theories, applying such knowledge to the research projects that supports Company interests.
  • Demonstrating technical proficiency, scientific creativity, and independent thought in suggesting experimental design and research strategy.
  • Presenting results of work in departmental or Company meetings, training fellow scientists in cell culture and molecular biology techniques
  • Perform nucleotide manipulation techniques such as DNA/RNA extraction, purification, quantification, PCR amplification, gel electrophoresis, restriction digestion, gel extraction, ligation.
  • Design and execute gene-editing experiments with mammalian cells, including iPSCs, in collaboration with our Cell Biology team.
  • Adapt quickly to adjust workload and priority based on project needs and assignments.

EDUCATION/EXPERIENCE/SKILLS:

Education:

  • Ph.D. in Biomedical Sciences, postdoc or industry research experience will be preferred.

Experience:

  • Requires a minimum of 3 years of relevant research experience.
  • Demonstration of strong publication record.
  • Research interest and experience in the mechanism of cardiac genome regulation, including epigenetic regulation, enhancer/promoter biology, and RNA editing and silencing.
  • Hands-on experience in constructing complex/large gene plasmids and production of recombinant proteins in bacteria or in insect cells.
  • Hands-on experience in histopathology, immunostaining, mouse echocardiography, transaortic constriction, and surgical instrumentation (such as catheterization) of mouse hearts
  • Hands-on experience in isolating primary cardiomyocytes (adult and neonatal mouse) and culturing iPS-derived cardiomyocytes and gene knockdown technology in those cells for molecular biology studies
  • Engineering of different heterologous expression systems, incl. bacterial, yeast, mammalian and insect cell systems is a plus.

Knowledge/Skills/Abilities:

  • Knowledge of heart failure pathogenesis
  • Ability to adapt, learn quickly and lead innovation
  • Strong background in molecular biology and use of animal models for disease studies
  • Ability to develop new techniques and methodologies as dictated by research need and introduce new technologies or methods to the team
  • Ability to stay current with the scientific literature and state of the art, as well as interpret literature results in light of new findings
  • Independence in problem solving and advancement of scientific projects toward common team goals
  • Proven track records on building great relationships within functions and cross-functionally in collaborative environment.
  • Exceptional communication, presentation, and data analysis skills.
  • Generation of new experimental protocols that may require developing new methods

Why You Should Apply

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion, and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

At BMS, our employees are committed to the following values:

  • Integrity – We demonstrate ethics, integrity, and quality in everything we do for patients, customers, and colleagues
  • Innovation – We pursue disruptive and bold solutions for patients
  • Urgency – We move together with speed and quality because patients are waiting
  • Passion – Our dedication to learning and excellence helps us to deliver exceptional results
  • Accountability – We all own BMS’ success and strive to be transparent and deliver on our commitments
  • Inclusion – We embrace diversity and foster an environment where we can all work together at our full potential

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.