Senior Principal Scientist Translational Medicine Hematology Multiple Myeloma
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us
Hematology Translational Medicine Disease Team at BMS
Translational Medicine is part of the Global Research and Early Development organization in BMS and leads mid to late stage clinical, pharmacological, and translational research and development activities for the BMS hematology pipeline and supports late-stage portfolio for translational development and life cycle management. Translational Medicine Hematology at BMS has a long-standing history of scientific rigor as evidenced by our peer-reviewed publications, delivery of drug approvals including Revlimid, Pomalyst, Idhifa, Inrebic, Reblozyl, Vidaza and Onureg, strong academic collaborations and talent development. Our areas of focus include but are not limited to Multiple Myeloma, Acute Myeloid Leukemia/MDS, Lymphoma and Erythroid disorders. This group integrates scientific learnings from the lab and clinic as well as business insights of multiple functions and leads the development of translational strategies at the franchise level.
Title: Principal Scientist/Senior Principal Scientist, Hematology Translational Medicine
Reporting to the Senior Principal Scientist, Hematology Translational Medicine, the role will be responsible for development and execution of drug and multiple myeloma disease-centric translational strategies in hematology for assigned asset programs. Key responsibilities of this role are to act as hematology asset lead scientists to deliver biomarker strategies for clinical programs, disease strategies for high-risk unmet need, patient selection, combination strategies and life-cycle management of our pipeline as well as regulatory support including pre-clinical and translational sections of NDA submissions. This individual will work on cross-functional project teams to drive execution of translational/biomarker plans working with laboratory scientists and BMS members from clinical, commercial, regulatory and diagnostics as well as engage external academic collaborators/Key opinion leaders (KOLs).
In-depth understanding of cancer biology/hematology, knowledge of clinical landscape, evolving therapy, competitive scenarios.
Strong understanding of clinical, translational, and mechanistic data.
Understanding of early or late-stage drug and translational development process; including clinical trial experience in industry or academia.
Experience in protocol authoring and informed consent form (ICF) review.
Working knowledge of technological platforms covering biomarker measures including but not limited to genomics, immune profiling, etc.
Proven ability to work with global disease teams to develop strategies to support drug life cycle management.
Strong verbal and written communication skills with experience in developing written documents such as primary manuscripts/publications/reviews, disease strategies, mechanism slides, regulatory submissions, literature/ patient segment/subpopulation analyses.
Proven scientific/project leadership expertise (working in teams, managing people/projects).
Ability to synthesize complex scientific and business problems into strategy.
Basic understanding of intellectual property, contracting terms and provisions.
Assists and leads the development of asset specific translational goals and objectives for the Hematology Translational Medicine group (for internal /external, translational collaboration, compound specific plans, etc.).
Represents Translational Medicine (TM) on cross-functional Strategy and Global Project Teams.
Supports regulatory submissions, regulatory interactions, writes translational sections for regulatory response and answers to regulatory queries for the TM group.
Communicates regularly and prepares and makes presentations within the department and externally as required.
Participates in translational research with the Hematology Laboratory.
Oversees biomarker plan development and execution in clinical trials, large genomic projects from human clinical samples, and clinical trial support (defined clinical experiments from the development teams). This includes development of high dimensional bioinformatics in collaboration with the Informatics and Predictive Sciences group.
Responsible for selection and delivery of Clinical PD or Biomarker assays, translated from discovery (if applicable or appropriate) or developed specifically for early clinical use, assessing feasibility and applicability for companion diagnostics.
Application of model systems (in collaboration with the disease biology and in vivo pharmacology groups) beyond those routinely employed by discovery teams that aid in patient stratification/response, dose optimization and therapeutic use, either in-house or through external collaborations.
May participate in BD and established teams to evaluate the potential in-licensing opportunities that will advance our Drug Discovery and Development pipeline.
May perform advisory and mentoring role for junior scientists.
Participate or present at scientific advisory boards to support drug programs/projects.
Assists in developing and maintaining group budget and workforce plan.
PhD in Hematology/Oncology or related field with min 3-6 years in industry and academic setting.
Strong track record in large and small biotech/pharmaceutical companies, leading translational/biomarker studies or innovative efforts to deploy technologies and assays for enhanced translational capabilities or similar skill sets in academia.
Proven track record of success in drug discovery and development.
Experience with translational/biomarker strategies for early or late stage clinical trials or investigator sponsored trials in academia.
Competence in analysis and solving of problems, and the ability to prioritize to achieve goals.
Excellent communication, managerial and scientific qualities are expected.
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
BMS is dedicated to ensuring that people with disabilities can perform complex functions through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, direct your inquiries to email@example.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.