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Principal Scientist (Chemo)proteomics & Mass Spec NIBR San Diego

Science and Research



San Diego, California, United States

85% of the proteome is currently undrugged. Join our effort to tackle a longstanding challenge in early drug discovery by identifying covalent small molecules that modulate the activity of these so far undrugged targets and pathways to positively impact human health. <br><br>In expansion of our global effort in covalent drug discovery, we are currently looking for a Principal Scientist to drive chemoproteomic efforts at our San Diego site. <br><br>Your responsibilities:<br><br>The successful candidate will utilize covalent probes to capture protein-ligand interactions and develop novel mass spectrometry-based chemoproteomic strategies to enable covalent library screening as well as rapid follow-up of screening hits using a variety of primarily mass spectrometry-based approaches. <br><br>As a member of highly multidisciplinary project teams focusing on early-stage drug discovery and covalency-enabled exploration of new modalities, the position offers considerable opportunities to branch out into other areas of drug discovery including probe design and target validation in vitro and in cells. <br><br>[#video#{#400,300#}#/video#]