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Senior Scientist – Gene Therapy Neuroscience (345094BR)

Science and Research




San Diego, California, United States

Over 900+ clinical trials validate that gene therapies are transforming the practice of medicine. <br><br>Ready to join a team committed to developing and commercializing gene therapies for patients and families devastated by rare neurological genetic diseases? Novartis is advancing cutting-edge science, starting with our proprietary gene therapy for the treatment of spinal muscular atrophy (SMA). We are in the midst of an incredible journey and are looking for passionate individuals to join us on this important mission.<br>Novartis is dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product is a proprietary gene therapy approved by the US Food and Drug Administration for the treatment of pediatric patients with SMA. In addition to developing a treatment for SMA, Novartis also plans to develop other novel treatments for rare neurological diseases, including Rett syndrome and a Friedreich’s ataxia.<br>Novartis is seeking a highly motivated and capable Senior Scientist to join our Research and Early Development team. The position entails leading activities in the In vitro pharmacology group, including developing and mentoring the team and supporting the advancement of research projects. The incumbent will work with Scientists within the Research and Development team, as well as across the organization and will report to the lab head of In Vitro Pharmacology.<br><br>What you'll be doing:<br>• Leverage strong understanding and knowledge of gene expression and cellular mechanism of action (MOA) for clinical candidate selection and cell-based assay development.<br>• Design and execute experiments to identify and optimize key parameters for cell potency assays for lot release <br>• Lead activities within the functional group for pipeline program R&D from both the bench and the desk. <br>• Coordinate group efforts and oversee Scientists and ongoing projects to facilitate teamwork.<br>• Develop team members, ensuring staff receive mentoring and constructive feedback to develop in the role and learn new capabilities.<br>• Partner with project team leaders to plan, coordinate, and monitor the timely execution and completion of various research projects.<br>• Oversee the maintenance of accurate, comprehensible, and contemporaneous laboratory notebooks.<br>• Present data to the internal senior management team and external collaborators.<br>• Timely provision of data and documentation in reports to support intellectual property filings, regulatory submissions, and interactions with FDA around new products.<br>[#video#{#400,300#}#/video#]