Biotransformation Scientist, PK Sciences

100,000 + people across 140 countries are working for Novartis to discover, develop and successfully market innovative products to prevent and cure diseases, to ease suffering, and to enhance the quality of life!<br><br>Biotransformation is a key discipline within the Drug Disposition (DD) unit of the Pharmacokinetic Sciences (PKS) department that is essential for the progression of small molecules and new modalities such as drug-protein conjugates, oligonucleotides, peptides and radio-ligands from preclinical discovery into human and up to regulatory filing.<br><br>PKS is currently seeking a laboratory-based associate to join the biotransformation team in Cambridge, MA. In this role, you will be joining a large global team of skilled and motivated drug metabolism scientists who closely collaborate with other groups both within and outside of PKS in a highly cross-functional environment.<br><br>As the successful candidate you will be adaptable, independently motivated, and challenge driven with a history that demonstrates strong interpersonal skills that encourage successful collaborative working relationships. In this role, you will work in a team environment to support programs through the conduct of drug metabolism studies designed to understand ADME properties, biotransformation pathways, and routes of elimination for a diverse portfolio of therapeutic modalities. Your major responsibilities will include planning, conducting and documenting experiments designed to investigate metabolic pathways and structural elucidation of metabolites formed from new drug candidates using state of the art high resolution mass spectrometers.<br><br>PKS offers many opportunities to diversify your skills and develop your career. You will be encouraged to interact with and present your findings to project teams and will be given development opportunities to increase your project management skills including representing the ADME function on project teams and serving as a part-time project team manager.<br><br>Your main accountabilities will include:<br>• Design and execution of biotransformation studies to assess metabolic pathways, soft-spot identification, structural elucidation, and bioactivation of drug candidates<br>• Organize and prepare experimental protocols and study reports with upload of results to a centralized database<br>• Presentation of key findings to project teams and/or other stakeholders<br>• Support discovery, pre-clinical, and clinical development studies (in vitro and in vivo) to aid drug candidate progression<br>• Assure quality standard guidelines and safe work practices are applied while working in the laboratories<br><br>[#video#https://www.youtube.com/watch?v=FIxJdzIn0mE{#400,300#}#/video#]