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Job Details

Bristol Myers Squibb

Senior Principal Scientist (DMPK Program Scientist)

Science and Research



Brisbane, California, United States

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

This role is part of the Nonclinical Research and Development (NCRD) group. NCRD is an integrated function with responsibility for characterizing nonclinical safety and disposition characteristics of the entire BMS Research and Development pipeline programs, with critical role from early discovery to submission of marketing authorization applications. We utilize our deep expertise in toxicology/pathology, ADME, PK/PD, biopharmaceutics and Bioanalytics in all modalities (small and large molecules, cellular therapies and other novel modalities) to collaborate with peer R&D functions to identify and solve issues, discover high quality drug candidates, enable their clinical development and successful marketing authorizations across the globe.

Position Summary

We are seeking an enthusiastic, self-motivated scientist to join our Drug Metabolism and Pharmacokinetic (DMPK) Group as a Senior Principal Scientist. The role is in the Pharmaceutical Candidate Optimization (PCO) department within NCRD and encompasses broad support for Discovery programs and has a diverse range of expertise in DMPK, toxicology, pharmaceutics, and bioanalytical sciences.

The selected candidate can sit in any of our sites located in: Brisbane, CA, Cambridge, MA, or Lawrenceville, NJ

Key Responsibilities

  • Provide subject matter expertise on absorption, distribution, metabolism, and excretion (ADME) and pharmacokinetic-pharmacodynamic (PK-PD) modeling in support of Discovery projects

  • Expected to take mechanistic approaches and design/conduct relevant experiments to understand drug disposition profiles and PK-PD relationships for issue resolution, program advancement, and translation of dosage regimens from preclinical to clinical

  • Represent the DMPK group in Discovery project teams and contribute to program science and strategies across the Discovery portfolio

Basic Qualifications

  • Bachelors Degree and 10+ years of academic and / or industry experience OR

  • Master’s Degree and 8+ years of academic and / or industry experience OR

  • Ph.D. or equivalent advanced degree in the Life Sciences and 6+ years of academic and / or industry experience


  • 2+ years of leadership experience

Preferred Qualifications

  • Ph.D. in pharmacokinetics, drug metabolism, biochemistry, or related discipline with >8 years of relevant experience or a B.S./M.S. with 12/14 years of relevant experience

  • A good understanding of DMPK and PK-PD principles is essential to this job. Experience in supporting Antibody Drug Conjugate programs is highly desired

  • Demonstrated problem-solving skills, critical/strategic thinking ability, and capability of integrating data across multiple sources are required

  • Hands-on experience in modeling and simulation and/or in silico approaches is highly desired

  • Strong communication skills, good interpersonal skills, and ability to work and collaborate in a cross-functional team setting are critical for this role


For California based positions the starting compensation for this job is a range from $159,000-$185,000, plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and the where the job is performed.

Final individual compensation will be decided based on demonstrated experience.

For more on benefits, please visit our

Eligibility for specific benefits listed on our BMS Careers site may vary based on the job and location.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

COVID-19 Information
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.