Job was saved successfully.
Job was removed from Saved Jobs.

Job Details


Bristol Myers Squibb

Senior Principal Scientist (DMPK Program Scientist) (R1558720-en-us-1)

Science and Research

Scientist

Yearly

No

Brisbane, California, United States

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

This role is part of the Nonclinical Research and Development (NCRD) group. NCRD is an integrated function with responsibility for characterizing nonclinical safety and disposition characteristics of the entire BMS Research and Development pipeline programs, with critical role from early discovery to submission of marketing authorization applications. We utilize our deep expertise in toxicology/pathology, ADME, PK/PD, biopharmaceutics and Bioanalytics in all modalities (small and large molecules, cellular therapies and other novel modalities) to collaborate with peer R&D functions to identify and solve issues, discover high quality drug candidates, enable their clinical development and successful marketing authorizations across the globe.

Position Summary

We are seeking an enthusiastic, self-motivated scientist to join our Drug Metabolism and Pharmacokinetic (DMPK) Group as a Senior Principal Scientist. The role is in the Pharmaceutical Candidate Optimization (PCO) department within NCRD and encompasses broad support for Discovery programs and has a diverse range of expertise in DMPK, toxicology, pharmaceutics, and bioanalytical sciences.

The selected candidate can sit in any of our sites located in: Lawrenceville, NJ, Cambridge, MA, or Brisbane, CA.

Key Responsibilities

  • Provide subject matter expertise on absorption, distribution, metabolism, and excretion (ADME) and pharmacokinetic-pharmacodynamic (PK-PD) modeling in support of Discovery projects

  • Expected to take mechanistic approaches and design/conduct relevant experiments to understand drug disposition profiles and PK-PD relationships for issue resolution, program advancement, and translation of dosage regimens from preclinical to clinical

  • Represent the DMPK group in Discovery project teams and contribute to program science and strategies across the Discovery portfolio

Qualifications & Experience

  • Ph.D. in pharmacokinetics, drug metabolism, biochemistry, or related discipline with >7 years of relevant experience or a B.S./M.S. with >12 years of relevant experience

  • A good understanding of DMPK and PK-PD principles is essential to this job

  • Demonstrated problem-solving skills, critical/strategic thinking ability, and capability of integrating data across multiple sources are required

  • Hands-on experience in conducting in vitro and/or in vivo experiments is required; experience in modeling and simulation and/or in silico approaches is a plus

  • Strong communication skills, good interpersonal skills, and ability to work and collaborate in a cross-functional team setting are critical for this role

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.