Genomics Translational Research Senior Scientist
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprised of scientists across multiple disciplines, we are responsible for the biology and translational science necessary to support drug development from target identification through to first-in-human studies.
We are seeking a highly motivated and experienced individual with genomics expertise to join the TME TRC Translational Research team at Bristol Myers Squibb in Redwood City, CA. As a member of the NGS team, the successful candidate will perform and develop NGS workflow assays to support biomarker identification and target discovery. The successful candidate will be responsible for the development, optimization, and execution of NGS processes including bulk or single cell transcriptomic, genomic, and epigenomic sequencing platforms. As a key contributor to translational research teams, the candidate will apply genomic methods to inform indication prioritization and pharmacodynamic biomarker discovery and develop prototype biomarker assays for implementation in clinical trials.
In the role as a Senior Scientist within the TME TRC Translational Research team, the ideal candidate:
Accountable for design of hypothesis-driven studies using genomic technologies to inform pharmacodynamics, mechanism of action, and patient stratification/selection.
Develops, validates, and applies NGS methods for various genomic, epigenomic and transcriptomic sequencing platforms.
Independently plans and executes routine genomic assays. Independently analyzes data, troubleshoots, and determines next steps, and communicates results and timelines to project teams.
Draft SOW and manage CRO-based genomic studies to ensure the timely completion of outsourced activities.
Partner closely with translational biomarker, bioinformatics, and discovery biology scientists to drive the advancement of therapeutic candidates.
Play a key role in providing the relevant translational input to discovery and translational projects as part of interdisciplinary teams.
7+ years of academic and / or industry experience
5+ years of academic and / or industry experience
Ph.D. or equivalent advanced degree in the Life Sciences
2+ of academic and / or industry experience
Strongly prefer PhD with either 2+ years of significant biopharmaceutical industry experience or postdoc in genomics field, or MS with 8+ years of relevant experience in genomics research in biopharmaceutical industry.
Previous experience in cancer biology or immuno-oncology with translational research experience highly preferred.
Requires extensive experience performing genomic assays including RNA preparation, qPCR, NGS library prep, and Nanostring analysis.
Familiarity with biomarker assay development (tumor tissue-based and peripheral genomics and transcriptomics) to guide experimental prioritization is preferred.
Proven track record of handling multiple high priority tasks in parallel with internal and external collaborators including CRO’s and academics.
Excellent verbal and written communication skills across all levels both within an organization and with external collaborators/companies with the ability to recognize, articulate, and accept calculated risks to make informed decisions.
Comfortable working in a collaborative manner in a fast-paced environment.
Willing to work as a topic expert, outside of a traditional functional environment, in a team unified around serving the assets.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
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