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Senior Scientist II - Mass Spectrometry

Science and Research



San Diego, California, United States

Over 900+ clinical trials validate that gene therapies are transforming the practice of medicine. As a Research Scientist II, you will have an opportunity to join the NIBR Biologics Center (NBC) and be at the cutting edge, leading the development of innovative medicines that can improve lives of patients.<br><br>What you'll be doing:<br>• Execute developability assessments of AAV gene therapies including but not limited to mass spectrometry characterization of AAV gene therapy candidates for identity, post-translational modification, and degradation analyses and optimize methods for specific AAV serotypes as needed. <br>• Apply physical-chemical analytical methods for orthogonal support of MS analyses (SEC, reverse phase LC, charge variant characterization etc).<br>• Develop targeted MS methods to quantify proteins in complex samples.<br>• Understanding of analytical and biophysical characterization of various gene therapies, and/or to work as the characterization representative on project teams and establish the analytical strategy for the program based off AAV molecule liabilities and critical quality attributes. <br>• Operate and maintain high end mass spectrometer instruments, perform data analysis and ELN/Genedata documentation, and author and/or review method development and technical reports.<br>• Work in a highly interdisciplinary and collaborative environment as part of the global NBC team and contribute to data analysis and interpretation, making technical presentations, and report writing<br>• Interact and collaborate with colleagues in biologics across Discovery and Development organizations.<br><br>[#video#{#400,300#}#/video#]