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Principal Scientist Crystallographic Structural Biology NIBR East Bay

Science and Research



Emeryville, California, United States

NIBR Emeryville, California, houses approximately 170 associates and includes medicinal chemistry, computer-assisted drug discovery, structural and biophysical chemistry, protein sciences, compound management, Institute for Tropical Disease research, a protein interactomics drug discovery center and analytical chemistry. Located in the heart of a key academic and biotechnology center, NIBR Emeryville collaborates with local institutions such as Stanford and the University of California campuses in Berkeley and San Francisco. <br><br>We seek a self-motivated, PhD-level scientist with extensive experience in structural biology to join our team in the Structural and Biophysical Chemistry group (SBC). The SBC is a multidisciplinary team with expertise in X-ray crystallography, NMR, and biophysics. Our team collaborates with scientists across NIBR at the frontiers of chemical biology, chemical genomics, data sciences, and disease biology to identify opportunities for next generation therapeutics. Our goal is to identify and develop small molecules with the potential for modulating diseases, and we support drug discovery projects in various therapeutic areas like oncology, immune-oncology, cardiovascular, respiratory, immunology and neurological diseases.<br><br>The Principal scientist will be an integral member of structure-based drug discovery teams, providing structural biology expertise to advance early drug discovery efforts, design and conduct innovative experiments to solve key scientific questions, communicate effectively and efficiently in team meetings and in review sessions, and collaboratively work with other scientists to develop innovative medicines. This role will impact our local discovery efforts and the global discovery portfolio through bench-level contributions. <br><br>Your responsibilities:<br><br>• Independently design, develop, and implement crystallographic and other structural biology techniques to support the Structure-based Drug Discovery efforts at Novartis. Analyze, interpret, and communicate results to the project teams. Document results in NIBR databases and notebooks, and communicate results to teams.<br>• Collaborate with members of the Structural and Biophysical Chemistry, Protein Science, CADD, and Medicinal Chemistry Groups to enable successful SBDD. Collaborate with interdisciplinary project teams globally to optimally drive the NIBR portfolio<br>• Contribute to cross-functional small molecule drug discovery project teams and provide expertise to enable key project decision points<br>• Contribute to multiple projects in parallel<br>• Identify opportunities to employ structural and biophysical methods to impact drug discovery. <br>• Identify innovations in structural methods for drug discovery. Apply or learn additional methods (e.g. biochemical, biophysical, or other analytical method) to early-stage discovery programs<br>• Be part of the local and global NIBR community by supporting our Curious, Inspired and Unbossed culture at Novartis<br><br>[#video#{#400,300#}#/video#]