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Principal Scientist, Translational Modeling & Simulation (349584BR)

Science and Research




Cambridge, Massachusetts, United States

6000! That is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. <br><br>The PK Sciences / Translational Modeling & Simulation group is embedded within the Translational Medicine department of NIBR. Our goal is to enable quantitative approaches to rigorous decision making, from target identification to first-in-human studies and beyond. Novartis has a broad pipeline of therapies across a wide number of disease areas. We are seeking a curious and proactive modeler to apply computational methods to drive the design, characterization, and delivery of low molecular weight (small molecule) compounds. These include reversible or covalent inhibitors and modulators, targeted protein degraders, soft drugs, and half-life extended compounds. Our group is growing, and we hope you will join us as we use computational modeling to generate new insights with both forward and reverse translational approaches.<br><br><b>Your responsibilities will include, but are not limited to: </b><br>• Act as the Translational M&S representative on several programs by developing and executing modeling strategies, collaboratively contributing to project team discussions.<br>• Build and apply PK/PD, quantitative systems pharmacology (QSP), and physiologically based PK (PBPK) models that link drug pharmacology, mechanism(s) of action, safety, and biological outcomes.<br>• Support the selection of molecules for efficient lead optimization and hypotheses testing by identification of pharmacokinetic liabilities.<br>• Develop a modeling-based strategy for preclinical projects and lead the project team discussions on the human dose prediction prior to candidate selection.<br>• Contribute to programs across therapeutic modalities (beyond small molecules), and across disease indications, as needed. Novartis has a broad portfolio with hundreds of drug discovery and clinical development projects and you will have opportunities to grow and develop.<br>• Proactively seek opportunities to increase the impact and awareness of translational modeling through communications with internal and external audiences. <br><br>[#video#{#400,300#}#/video#]