Senior Scientist Protein Homeostasis Structural Biology
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
Senior Scientist, Protein Homeostasis Structural Biology
BMS is a leader in the discovery and development of novel therapies that exploit targeted protein degradation. Structural biology is critical to our protein homeostasis (PH) research. High-quality 3D structures of proteins and protein complexes involved in Ubiquitin/Proteasome System-mediated degradation enable our scientists to understand mechanisms of action, design ligands or drug molecules, and make predictions about new biological targets for our drug discovery efforts. A deep focus in Oncology puts our resources squarely on projects of intense biomedical interest.
The successful candidate will perform and direct research within a talented group of structural biologists and will focus their experience and expertise in the PH field. There is opportunity to have a real-time, high-value impact on the ongoing projects as well as chart the future of our research efforts by capitalizing on structural insights, for example by uncovering mechanisms of action, defining binding modes, and identifying target degrons. The scientist will interface with chemistry, biology, proteomics, and computer-aided drug design scientists working on our PH projects. The PH Structural Biology team is part of an exciting and vibrant group that includes proteomics, biophysics, and cell biology, all with a focus on PH. We are seeking a passionate scientist who strives to bring impactful structural biology insights to bear on a burgeoning portfolio of PH targets, with the goal of bringing novel therapies to patients.
- Plan, execute, and report on studies resulting in novel structures for CRBN E3 Ligase Modulators (CELMoDs) and Ligand Directed Degraders (LDDs)
- Lead structural biology efforts pursuing novel ligands for ubiquitin ligases and other PH targets
- Represent the PH Structural Biology team at project level meetings, and experimentally support multiple projects in parallel
Bachelor's Degree with 7+ years of academic or industry experience
Master’s Degree with 5+ years of academic or industry experience,
Ph.D. with 2+ years of academic or industry experience
- Ph.D. with 2+ years of industry experience
- Candidates with significant drug discovery experience in an industrial setting will be given preference
- Training and expertise in X-ray crystallography or single-particle cryo-electron microscopy for the elucidation of protein structure
- In-depth knowledge of current practices, instrumentation, and issues for answering key structural biology questions with a focus on enzymes and large protein complexes
- Experience in protein construct design, expression, and purification
- Strong written and oral communication skills to clearly deliver scientific results and presentations
- Demonstrated ability to thrive as part of a multidisciplinary team and inspire mutually beneficial collaborations to drive the development of PH therapeutics
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
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