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Principal Scientist, Cardiovascular Safety Pharmacologist

Science and Research



Cambridge, Massachusetts, United States

If you are interested in the dynamic field of safety pharmacology, we have a role that encompasses nearly all aspects of the discipline. Partnering with external providers, oversight and monitoring of all ICH S7a guidance studies is a primary responsibility of the role. As well, connectivity with aspects of toxicology investigations (ECG subject matter expertise). Follow-up investigational studies for all therapeutic areas, to design, set-up, and support results interpretation are included in this role. Good organizational skills, diplomatic communication style, target team translation discussions are characteristics of the optimal candidate’s skill set.<br><br>Your responsibilities will include, but are not limited to:<br>•Participates in and/or lead multidisciplinary teams together with scientists from other units in Novartis; will work with external partners monitoring outsourced studies. Leads safety pharmacology projects and monitors GLP/investigative studies, integrating independent experimental work to develop translational assessments.<br>•Builds increasingly broad scientific/technical/development toolkit for self and team, and deepens own technical/scientific specialty that enables the NIBR community in own areas of expertise.<br>•Enables matrix collaboration on project/technology solutions to achieve creative results for impact on project goals. Generates innovative ideas within diverse therapeutic areas and/or project team/target team community to answer key scientific/technical/development questions. Establishes target dates and priorities to enable data-driven advancements in project teams, monitoring collaborative safety pharmacology investigations CV-Resp-CNS, for the project axis community.<br>•Systematically develops and recommends study objectives for project teams surrounding own area of expertise, and provides input to broader group objectives, overseeing studies/guiding and empowering associates in team or enabling matrix/junior collaborators. Provides coaching and leadership to facilitate drug safety endpoints and/or early development solutions for projects.<br>•May supervise scientists and ensure compliance to all protocols, procedures, animal welfare, safety, OSHA regulations and company policies. Shall function as a leader in technical excellence (displays a high level of competence in ECG/cardiac dynamics as well as laboratory technical procedures), and diplomatic communication outside the group.<br>•Apply scientific knowledge to encourage the use of new methodologies/techniques and optimize existing models/methods. Compliance, safety, and quality are critical and must be the driving force for all activities. Meeting timelines, budget-compliance, and coordination of activities within other internal functions and external customers are also of high priority. May be assigned to Study Monitor duties outside of safety pharmacology investigations, and other tasks/workstreams by management.<br><br>[#video# {#400,300#}#/video#]