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Bristol Myers Squibb

Senior Scientist, Oncology Discovery

Science and Research

Scientist

Yearly

No

Cambridge, Massachusetts, United States

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Oncogenesis Thematic Research Center (TRC) at BMS is one of the fundamental research and early development engines delivering therapeutics to cancer patients, integrating early discovery research through translational and early clinical development. Our modality focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system, protein translation, and RNA processing and stability allowing the group to capitalize on the cutting edge science that underpins the action of the company’s most advanced drugs. Pioneering research around these modalities creates a very dynamic, exciting and creative environment that exploits excellent science in biology, biochemistry, structural biology, computational biology and translational development.

The Discovery Biology group within the Oncogenesis (TRC) focuses on delivering novel cancer therapeutics by engaging E3 ubiquitin ligases for targeted protein degradation. We are seeking a highly motivated Cancer Biologist with broad experience in tumor biology and immuno-oncology to participate in the discovery of novel targeted protein degradation drugs for hematology oncology projects. The successful candidate will work collaboratively in a multi-disciplinary environment to 1) explore disease biology enabling identification of novel drug targets; 2) develop and implement robust cellular and immune assays to support discovery of small molecules as clinical development candidates; 3) design and execute research strategies that further our understanding of the mechanisms of novel compounds and targets; and 4) develop collaboration and interact with external partners relevant to the target discovery efforts. The successful candidate will work both independently and within discovery project teams across different functional areas and be expected to present her or his work at project team meetings and to senior research leadership.

Responsibilities will include, but are not limited to:

  • Utilize and develop multiple disease models to design target validation studies and relevant assays in support of SAR, mechanism of action, mechanisms of resistance, biomarker selection, and disease positioning.
  • Work independently to formulate hypothesis, design, execute, analyze, interpret and troubleshoot scientific experiments on both intrinsic cellular biology and immune-based mechanisms of action.
  • Accurately maintain written reports and present results in an organized and timely manner.
  • Communicate effectively, foster teamwork and contribute to project strategy discussions.
  • Strong commitment to quality and demonstrate adaptability.

Skills/Knowledge Required:

  • Extensive experience using multi-parameter flow cytometry in the context of primary immune cell isolation and T cell biology is required.
  • Strong background utilizing platforms including IncuCyte, Western blot, ELISA/MSD, and functional assays such as cytotoxicity, cell cycle and apoptosis in the context of oncology-based drug discovery is a plus.
  • Hands-on experience in mammalian cell culture using primary, single and/or co-culture cell models, including genetic manipulation techniques such as CRISPR RNP nucleofection and/or lentiviral transduction.
  • Strong record of high-impact and rigorous science though publication history.
  • Proficiency in scientific and data analysis programs including FlowJo, Microsoft Excel, PowerPoint, GraphPad Prism is required.
  • Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude and independently collaborate across teams, requiring excellent communication skills, both written and verbal, with strong interpersonal skills.

PREREQUISITES

Ph.D. in cell biology, immunology, molecular biology or equivalent field with 3+ years of post-doc or industry experience, or M.S. degree with a minimum of 10 years industry experience developing and optimizing cell-based assays.

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Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.