Principal Scientist - DMPK
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
Nonclinical Research and Development (NCRD) is an integrated function with responsibility for characterizing nonclinical safety and disposition characteristics of the entire BMS Research and Development pipeline programs, with critical role from early discovery to submission of marketing authorization applications. We utilize our deep expertise in toxicology/pathology, ADME, PK/PD and Bioanalytics in all modalities (small and large molecules, cellular therapies and other novel modalities) to collaborate with peer R&D functions to identify and solve issues, discover high quality drug candidates, enable their clinical development and successful marketing authorizations across the globe.
We are seeking a highly enthusiastic and self-motivated scientist to join our Drug Metabolism Group as a Principal Scientist at our Princeton, NJ site. The role is in the Pharmaceutical Candidate Optimization (PCO) department within our NCRD funcation. It encompasses broad support for Discovery programs with expertise in DMPK, toxicology, pharmaceutics and bioanalytical sciences.
In this role, the candidate will provide subject matter expertise on absorption, distribution, metabolism and excretion (ADME) for Discovery programs, and will be responsible for designing and conducting mechanistic in vitro and in vivo studies to understand and resolve issues to drive impact in our discovery efforts. There will be a major emphasis on working with Discovery project teams specifically at our Princeton, NJ site, but the candidate will be expected to contribute to program science and strategy across the Discovery portfolio, with potential collaborations at our Redwood City, CA, San Diego, CA and Cambridge, MA sites.
Bachelor's Degree and 8+ years of academic / industry experience
Master's Degree and 6+ years of academic / industry experience
PhD and 4+ years of academic / industry experience
Ph.D. in pharmacokinetics, drug metabolism, medicinal chemistry or related discipline with a minimum of 5 years of relevant industrial experience highly preferred.
At the Principal Scientist level, the candidate should have a proven level of evidence of leadership in DMPK science and proven track record of scientific achievement through project influence and publication.
Experience with small molecule DMPK strategies is essential, and experience with biologics or other novel modalities is desired.
The position requires an in-depth expertise in drug metabolism with a broad-based understanding of in vitro and in vivo techniques used to characterize drug metabolism, as well as an advanced metabolite identification skill set in order to apply knowledge across a variety of modalities (eg. small molecule, ADC, peptides, large molecules).
An ideal candidate would also possess a reasonable understanding of pharmacokinetics in order to integrate data across sources to understand clearance pathways/mechanisms associated with compound disposition.
In addition, a strong interest in evaluating new technologies and designing new assay to enhance capabilities and support innovation within the group is desired.
The ideal candidate must possess excellent oral and written communication skills, and a good mentor for junior or non-ADME scientists.
The ability to collaborate and build strong relationships with other disciplines in PCO (discovery toxicology, discovery pharmaceutics and bioanalytical research) for issue resolution and program advancement is essential.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
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