Pathology Research Sr. Scientist - Advanced Imaging
Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.
We are seeking a motivated, experienced scientist with experience in tissue-based assays and image analysis to support discovery and translational research in our pathology group. The successful candidate will implement molecular and histopathological techniques to multiplexed imaging and apply quantitative image analysis to identify novel biological targets for cancer therapy and elucidate mechanism of action. Experience with the Akoya Phenocycler and/or Vectra systems, as well as comfort and facility with image analysis software and/or opensource tools are highly desirable.
The successful candidate will:
Develop and validate staining protocols and analysis parameters for quantitation of multiplexed assays examining various molecular targets in intact human tissues.
Develop and apply analytic methods to phenotype cell populations and quantitate and spatially characterize molecular targets in situ within tissue sections.
Interact seamlessly with pathologists, IHC bench scientists, histotechnicians, and other stakeholders to drive projects with quantitative imaging endpoints.
Serve as a representative of the Anatomic Pathology group and a functional area expert on project teams.
Present data in team meetings and participate in generation of technical reports in support of regulatory documents.
This position will require excellent communication and interpersonal skills, high capacity and enthusiasm to work collaboratively with others both within and outside the department, and a strong drive to solve problems, overcome obstacles, and innovate. The successful candidate will have a high level of comfort with complex multitasking; be self-motivated and productive; and be able to work independently, with minimal oversight.
Bachelor or Graduate degree with extensive related experience; PhD (biology, pathology, immunology, oncology or related field) strongly preferred.
Required Skills and Experience:
Experience with immunohistochemistry and multiplexed immunofluorescence.
Experience with digital whole-slide images visualization and quantitative image analysis.
Preferred Skills and Experience:
Significant scientific engagement and leadership as evidenced through publications and presentations.
High level of comfort with histology/microanatomy strongly preferred.
Experience in processing and manipulating large datasets with R or Python programming language.
Background in immunology, pathology, oncology, and/or computational biology.
Background in machine learning.
Previous experience in the pharmaceutical industry.
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.
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In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
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Travel Requirements:No Travel Required
Flexible Work Arrangements:
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Number of Openings:1