Principal Scientist, DMPK Project Representative

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

Nonclinical Research and Development (NCRD) is an integrated function with responsibility for characterizing nonclinical safety and disposition characteristics of the entire BMS Research and Development pipeline programs, with critical role from early discovery to submission of marketing authorization applications. We utilize our deep expertise in toxicology/pathology, ADME, PK/PD, biopharmaceutics and Bioanalytics in all modalities (small and large molecules, cellular therapies and other novel modalities) to collaborate with peer R&D functions to identify and solve issues, discover high quality drug candidates, enable their clinical development and successful marketing authorizations across the globe.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

The Principal Scientist will be responsible for representing Nonclinical Disposition and Bioanalysis (NDB) on cross-functional project teams and collaborating closely with multiple departments to address drug development issues associated with drug candidates. With guidance he/she will prepare regulatory dossiers/responses and oversee developmental drug metabolism and non-clinical pharmacokinetics activities of multiple projects.

Responsibilities will also include, but are not limited to, the following:

• Represent NDB on cross-functional project teams, including preparation of project development plans.

• Collaborate closely with Clinical Pharmacology, Preclinical Compound Optimization, Toxicology, Pharmacology, and other groups to address project related issues.

• Prepare submission documents such as CTD sections for INDs, Investigator Brochures, Briefing Books, etc.

• Contribute to internal and outsourced drug metabolism and PK activities by providing input on study design, data interpretation, and report review.

• Apply novel techniques and approaches to address ADME and DDI issues.

• Keep management apprised of project status and current scientific trends using written and oral summaries, as well as presentations.

• Ability to use ADME modeling and simulation software (Phoenix- WinNonlin, GastroPlus, SimCYP) is a plus.

Basic Qualifications:

• Bachelor’s Degree and 8+ years of academic and / or industry experience OR

• Master’s Degree and 6+ years of academic and / or industry experience OR

• Ph.D. or equivalent advanced degree in the Life Sciences and 4+ of academic and / or industry experience

Preferred Qualifications and Experience

• Understanding of in vitro and in vivo techniques used to characterize drug metabolism, pharmacokinetics and drug interactions potential of drug candidates.

• Effective working with interdisciplinary project teams, including developing ADME drug development plans.

• Understanding of regulatory requirements in the areas of drug metabolism, drug-drug interactions, and clinical pharmacology.

• Experience preparing drug metabolism reports and regulatory submission documents.

• Strong written and verbal communication skills, computer proficiency, and experience with modeling software are required.

• Ability to multi-task and work in a collaborative team environment

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

COVID-19 Information
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.