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Job Details

Bristol Myers Squibb

Principal Scientist - Cell Line Development

Science and Research



Summit, New Jersey, United States

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

Bristol-Myers Squibb Biologics Development has Cell Line and ’Omics Development organization comprising Cell Line Development, Molecular biology, and Multi-Omics, is co-located with Upstream Process Development, Downstream Process Development, Process Analytics, and Analytical Development organization in New Brunswick and Summit sites in New Jersey and Devens site in Massachusetts. BMS New Jersey sites are part of New Jersey’s “Biopharmaceutical Life Sciences Cluster,” a concentrated area of biotechnology, medical device, and pharmaceutical companies.

Position Description:

Reporting to the Head of Cell Line Development sub-team in BMS-Summit, NJ site, the successful candidate will focus on the development of mammalian cell lines in the production of monoclonal antibody and other types of recombinant proteins, including bi-specific antibody, fusion protein, and antibody drug conjugates, for clinical and commercial manufacturing. The incumbent will work closely with other functional groups such as R&D, molecular biology, upstream process development and process development analytics.

Key Responsibilities:

  • Lead cell line development project and performs key activities associated with production cell line development including transfection, selection, single cell cloning, high throughput screening, characterization of clonal cell lines using scale-down models, cell banking, and cell line stability studies.
  • Evaluate and introduce innovative technologies to improve cell line development process and therapeutic protein production
  • Understanding IP landscape of novel technologies in cell line development and developing a strategy to ensure freedom to operate.
  • Managing cell line development projects with external partners and outsourcing activities.
  • Managing tech transfer activities to support cell banking, cell bank testing, and drug substance manufacturing.
  • Working closely with discovery, upstream and downstream process development, as well as analytical development teams to support drug substance development of BMS Biologics pipeline.
  • Serving as SME to support cell line development in cross functional CMC teams as well as author/review regulatory filings for early and late stage projects.
  • Writing technical reports and presenting data in internal meetings.
  • Supervising direct reports and providing mentorship to a growing team.


  • PhD in Biological Sciences, Molecular Biology, Biochemical Engineering, or relevant discipline and minimum 6 years of relevant industrial experience, MS with over 12 years relevant experience.
  • Extensive experience with cell line development for production of monoclonal antibody, fusion proteins, bi-specific antibody and other complex modality of Biologics.
  • Experience with DNA cloning, vector construction and design, and genetic characterization of production cell banks is required.
  • Hands on experience with high throughput immunological assays such as Octet assay, ELISA, and FACS analysis.
  • Experience with operating AMBR microbioreactor and automated liquid handling system will be a plus
  • Experience with AAV viral expression system development and production will be plus
  • In depth knowledge of antibody technology and protein expression as well as a good understanding of regulatory guidelines for human therapeutics.
  • The candidate must be well organized and have excellent oral and written communication skills.
  • Demonstrated ability to think critically as well as possess excellent problem-solving skills.
  • Proven record on publication in peer reviewed journals and presentations in conference.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.