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Job Details

Bristol Myers Squibb

Senior Principal Scientist Machine Learning / Protein Design Prediction

Science and Research



Cambridge, Massachusetts, United States

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

Job Description

We are seeking a collaborative machine learning scientist with expertise in protein structure prediction and design to join the Predictive Sciences team. You will be responsible for the research and development of innovative computational approaches and workflows to design and optimize proteins. This role provides the opportunity to leverage large-scale proprietary datasets and work with subject matter experts on cross-functional teams to solve challenging problems in how we discover and engineer the next generation of biotherapeutics.


  • Pioneer machine learning research into antibody-antigen interaction modeling and design using internal and external datasets.
  • Partner with project teams to advance sequence- and structure-based antibody discovery and design.
  • Develop and implement computational approaches and prediction algorithms that can map linear and three-dimensional epitopes, optimize binding scaffolds and library design to guide screening, identify and mature the affinity of antibody hits, and assess potential liabilities and optimal development options.
  • Communicate findings and recommend follow-up actions in multiple settings such as 1:1, seminars, group, and project meetings.

Basic Qualifications

  • Bachelor's Degree in structural bioinformatics, computer science, engineering, statistics, or similar and 10+ years of academic / industry experience

  • OR Master's Degree in structural bioinformatics, computer science, engineering, statistics, or similar and 8+ years of academic / industry experience

  • Ph.D. in structural bioinformatics, computer science, engineering, statistics, or similar with 8+ years of relevant experience.

Preferred Qualifications

  • Ph.D. in structural bioinformatics, computer science, engineering, statistics, or similar with 8+ years of relevant experience.
  • Deep expertise in modern neural network architectures including transformers, autoencoders, GANs, attention models. Familiarity with Tensorflow/JAX and its ecosystem, as well as other platforms such as scikit, and design of effective experiments and metrics.
  • Experience with state-of-the-art machine learning approaches applied to biological sequence data (RNA, DNA, proteins) in the molecular and cell biology domains.
  • Proven track record of contributing to and helping advance multi-disciplinary team projects.
  • Expertise with a high-level programming language such as R or Python for sophisticated data analysis and reproducible research practices.
  • Scientific curiosity with an ability to identify questions machine learning approaches can address, and the skills to develop solutions both independently and collaboratively.
  • Excellent problem-solving skills and teamwork.
  • Strong communication, data presentation, and visualization skills.
  • Knowledge in biochemistry or protein engineering is a plus.

The starting compensation for this job is a range from $159,000-$185,000, plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and the where the job is performed.

Final individual compensation will be decided based on demonstrated experience.

For more on benefits, please visit our

Eligibility for specific benefits listed on our BMS Careers site may vary based on the job and location.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

COVID-19 Information
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

BMS is dedicated to ensuring that people with disabilities can perform complex functions through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.