Sr. Scientist Early Target Biology

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us

The Mechanisms of Cancer Resistance Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies, and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

The new Bristol-Myers Squibb research site in Cambridge’s Kendall Square will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation and business opportunities.

The Sr. Scientist will join the Early Target Biology group at Bristol-Myers Squibb in Cambridge, MA and aide and lead in the advancement of early-stage therapeutic targets. The position will utilize and develop cellular biological assays, genome engineering, and functional genomics to validate tumor intrinsic targets that confer resistance to targeted- and immuno-therapies.

The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment and aid and lead the advancement of the next wave of targets into preclinical drug development. The candidate is expected to effectively collaborate with colleagues across Discovery Oncology including the Exploratory Pharmacology, Drug Discovery and Translational Research groups. The successful candidate will demonstrate clear and professional verbal and written communication skills and will be capable of communicating these results across multidisciplinary teams. The position requires the ability to design, iterate, and champion key project initiatives and demonstrate critical thinking to challenge self and others.

Qualifications and Key Responsibilities

• A B.S. with a minimum of 7 years of experience, an M.S. with a minimum of 5 years of academic/industrial experience or Ph.D. in Genetics/Genomics, Molecular or Cellular Biology.
• Scientific training and experience in developing and executing functional genomics screening technologies for the purpose of identifying and validating novel targets, understanding therapeutic concepts and modalities, and deciphering mechanism of action
• Strong scientific and hands-on experience using a wide range of cellular and molecular biology techniques, including tissue culture, flow cytometry, immunoprecipitation (IP), CHIP Seq analysis, ELISA, assay development, is preferred. Use of gene perturbation techniques (eg shRNA, CRISPR-mediated genome editing), qRT-PCR, cell proliferation assays, molecular cloning, and lentivirus generation and transduction is a requirement.
• Demonstrated ability to leverage cutting-edge genomics technologies for target discovery, functional validation, and delivery of target and disease-relevant findings in a multi-functional, highly interactive and matrix environment
• Experience in cancer genome data mining by using desktop tools/interfaces and public databases (e.g., CBIO, TCGA, CCLE, Genepattern etc) is highly desirable.
• Proficiency in utilizing software such as Graph Pad, Microsoft office etc. for data analysis and figure generation is required.
• Ability to lead, design, and execute on project initiatives and operates to a high standard. Attention to detail with excellent organizational and record keeping skills is a requirement.
• Excellent interpersonal skills with the ability to interact effectively with people, internally and externally, is required.
• This position is located in Cambridge, MA. There will be less than 10% travel.

At BMS, our employees are committed to the following values:

• Integrity – We demonstrate ethics, integrity, and quality in everything we do for patients, customers, and colleagues
• Innovation – We pursue disruptive and bold solutions for patients
• Urgency – We move together with speed and quality because patients are waiting
• Passion – Our dedication to learning and excellence helps us to deliver exceptional results
• Accountability – We all own BMS’ success and strive to be transparent and deliver on our commitments
• Inclusion – We embrace diversity and foster an environment where we can all work together at our full potential

Why You Should Apply

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

COVID-19 Information
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

BMS is dedicated to ensuring that people with disabilities can perform complex functions through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.